Mao Qunxia, Gao Linggen, Liu Qing, Zou Yan, Yang Xvhui, Wang Hongwei, Wang Qian, Yu Hua
National Research Institute for Family Planning, General Hospital of Chinese People's Liberation Army, Beijing;
Department of Geriatric Cardiology, General Hospital of Chinese People's Liberation Army, Beijing;
Biomed Rep. 2013 Mar;1(2):259-264. doi: 10.3892/br.2013.58. Epub 2013 Jan 21.
Previous studies have reported the association between A10389G polymorphism of the () gene and breast cancer risk with conflicting results. To explore this association, we conducted a meta-analysis on 5,580 patients and 5,749 controls from eligible published studies. Six reports (11 study populations) were included in this meta-analysis. Compared with the individuals with the G allele, individuals carrying the A allele did not exhibit increased breast cancer risk. The odds ratio (OR) and 95% confidence interval (CI) were 1.02 and 0.79-1.31, respectively. Stratified analyses were carried out according to ethnicity and source of controls. The corresponding ORs (95% CIs) were 1.20 (0.90-1.86) for African-American, 0.47 (0.03-7.64) for European and 0.89 (0.70-1.14) for mixed populations, respectively. A single study on Asian populations yielded an OR (95% CI) of 0.56 (0.32-1.00). The corresponding ORs (95% CIs) were 1.12 (0.23-5.47) for hospital-based studies, and 0.98 (0.76-1.27) for population-based studies. Only one study did not mention the source of control, the OR (95% CI) of which was 1.80 (1.15-2.82). Results of the present study suggested that the gene A10389G polymorphism may not be an independent risk factor for breast cancer. However, additional studies should be performed to clarify the possible roles of the A10398G polymorphism in the etiology of breast cancer.
先前的研究报道了（）基因的A10389G多态性与乳腺癌风险之间的关联，但结果相互矛盾。为了探究这种关联，我们对符合条件的已发表研究中的5580例患者和5749例对照进行了荟萃分析。该荟萃分析纳入了6篇报告（11个研究群体）。与携带G等位基因的个体相比，携带A等位基因的个体并未表现出乳腺癌风险增加。比值比（OR）和95%置信区间（CI）分别为1.02和0.79 - 1.31。根据种族和对照来源进行了分层分析。非裔美国人的相应OR（95%CI）为1.20（0.90 - 1.86），欧洲人的为0.47（0.03 - 7.64），混合人群的为0.89（0.70 - 1.14）。一项针对亚洲人群的单独研究得出的OR（95%CI）为0.56（0.32 - 1.00）。基于医院的研究的相应OR（95%CI）为1.12（0.23 - 5.47），基于人群的研究的为0.98（0.76 - 1.27）。只有一项研究未提及对照来源，其OR（95%CI）为1.80（1.15 - 2.82）。本研究结果表明，（）基因的A10389G多态性可能不是乳腺癌的独立危险因素。然而，应进行更多研究以阐明（）基因A10398G多态性在乳腺癌病因学中的可能作用。
