Mao Qunxia, Gao Linggen, Wang Hongwei, Wang Qian, Zhang Tong
National Research Institute for Family Planning, Beijing, China.
General Hospital of Chinese People's Liberation Army, Beijing, China.
Asia Pac J Public Health. 2015 Mar;27(2):NP36-46. doi: 10.1177/1010539512446962. Epub 2012 May 31.
Published data regarding the association between alcohol dehydrogenase (ADH) 1C genotypes and breast cancer risk show conflicting results. The authors performed this meta-analysis on 1969 patients and 2244 controls from 4 (including 7 study populations) related case-control studies to estimate the association between ADH1C(rs698) genotyping information and breast cancer risk. According to the 6 eligible populations, the odds ratios (ORs) and 95% confidence intervals (CIs) for breast cancer risk for ADH1C (1-2) versus ADH1C (2-2) , ADH1C (1-1) versus ADH1C (2-2) genotype, and ADH1C (1) versus ADH1C (2) were 1.16 (0.95-1.42), 1.17 (0.95-1.44), and 1.05 (0.96-1.16), respectively. The OR (95% CI) for ADH1C (1-1) + ADH1C (1-2) versus ADH1C (2-2) from the 7 study populations was 1.14 (0.96-1.36). Meanwhile, genotypes of ADH1C (1-1) + ADH1C (1-2) increased the risk of breast cancer in drinkers (OR = 1.35; 95% CI = 1.03-1.76). This meta-analysis suggested that the ADH1C (1) allele might modestly influence the effect of alcohol on breast cancer but is not an independent risk factor for breast cancer. However, more restricted prospective studies are needed.
关于酒精脱氢酶（ADH）1C基因分型与乳腺癌风险之间关联的已发表数据显示出相互矛盾的结果。作者对来自4项（包括7个研究群体）相关病例对照研究的1969例患者和2244例对照进行了这项荟萃分析，以评估ADH1C（rs698）基因分型信息与乳腺癌风险之间的关联。根据6个符合条件的群体，ADH1C（1-2）与ADH1C（2-2）、ADH1C（1-1）与ADH1C（2-2）基因型以及ADH1C（1）与ADH1C（2）的乳腺癌风险优势比（OR）和95%置信区间（CI）分别为1.16（0.95-1.42）、1.17（0.95-1.44）和1.05（0.96-1.16）。来自7个研究群体的ADH1C（1-1）+ADH1C（1-2）与ADH1C（2-2）的OR（95%CI）为1.14（0.96-1.36）。同时，ADH1C（1-1）+ADH1C（1-2）基因型增加了饮酒者患乳腺癌的风险（OR = 1.35；95%CI = 1.03-1.76）。这项荟萃分析表明，ADH1C（1）等位基因可能会适度影响酒精对乳腺癌的作用，但不是乳腺癌的独立危险因素。然而，还需要更严格的前瞻性研究。
