白细胞介素-10介导的宫颈癌调节中的矛盾现象。
The paradox of IL-10-mediated modulation in cervical cancer.
作者信息
Wang Yan, Liu Xiao-Hong, Li Yue-Hong, Li Ou
机构信息
Department of Gynaecology and Obstetrics, Affiliated Hospital of Hebei United University;
Departments of Pharmacy, Tangshan, Hebei 063000, P.R. China.
出版信息
Biomed Rep. 2013 May;1(3):347-351. doi: 10.3892/br.2013.69. Epub 2013 Feb 26.
Abstract
Interleukin-10 (IL-10) has opposing effects as an anti-inflammatory (potentially cancer-promoting) and antiangiogenic (potentially cancer-inhibiting) agent. The role of IL-10 in cervical cancer is also dual. Here, we review the IL-10-mediated tumor-promoting effect and tumor-inhibiting effects in cervical cancer, among which, human papilloma virus (HPV), human leukocyte antigen-G (HLA-G) and IL-10 polymorphisms are associated with the development of cervical cancer. IL-10 is also used for the therapy of cervical cancer through enhancing proliferation, expression of immunologically important surface molecules and increasing Th1 cytokine production and cytotoxic potential in HPV-specific CD8 (+) cytotoxic T lymphocytes.
摘要
白细胞介素-10（IL-10）作为一种抗炎（可能促进癌症）和抗血管生成（可能抑制癌症）因子具有相反的作用。IL-10在宫颈癌中的作用也是双重的。在此，我们综述了IL-10介导的宫颈癌促肿瘤作用和抑肿瘤作用，其中人乳头瘤病毒（HPV）、人类白细胞抗原-G（HLA-G）和IL-10基因多态性与宫颈癌的发生发展相关。IL-10还通过增强HPV特异性CD8（+）细胞毒性T淋巴细胞的增殖、免疫重要表面分子的表达以及增加Th1细胞因子的产生和细胞毒性潜能，用于宫颈癌的治疗。
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