胸苷酸合成酶、胸苷磷酸化酶和二氢嘧啶脱氢酶表达在接受基于5-氟尿嘧啶辅助化疗的胆道癌患者中的预后意义
Prognostic significance of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in biliary tract cancer patients receiving adjuvant 5-fluorouracil-based chemotherapy.
作者信息
Kim Kwan Woo, Kwon Hyuk-Chan, Kim Sung-Hyun, Oh Sung Yong, Lee Suee, Lee Ji Hyun, Roh Myung Hwan, Kim Min Chan, Kim Ki Han, Kim Young Hoon, Roh Young Hoon, Jeong Jin Sook, Kim Hyo-Jin
机构信息
Department of Surgery, Haeundae Paik Hospital, College of Medicine, Inje University;
Departments of Internal Medicine, College of Medicine, Dong-A University, Busan, Republic of Korea.
出版信息
Mol Clin Oncol. 2013 Nov;1(6):987-994. doi: 10.3892/mco.2013.166. Epub 2013 Aug 6.
Abstract
Biliary tract cancer (BTC) is a relatively uncommon type of cancer, accounting for ∼4% of the malignant neoplasms of the gastrointestinal tract. The aim of this study was to determine whether the expression of thymidylate synthase (TS), thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) predict clinical outcome in BTC patients treated with adjuvant 5-fluorouracil (5-FU)-based chemotherapy. TS and TP expression were found to be significantly correlated with cancer location (P=0.044 and 0.031, respectively). The multivariate analysis revealed that age [hazard ratio (HR)=2.157, P=0.008], stage (HR=2.234, P<0.001), resection margin status (HR=2.748, P=0.004) and TP expression (HR=2.014, P=0.039) were independently associated with overall survival (OS).
摘要
胆管癌（BTC）是一种相对罕见的癌症类型，约占胃肠道恶性肿瘤的4%。本研究的目的是确定胸苷酸合成酶（TS）、胸苷磷酸化酶（TP）和二氢嘧啶脱氢酶（DPD）的表达是否能预测接受基于5-氟尿嘧啶（5-FU）辅助化疗的BTC患者的临床结局。发现TS和TP表达与癌症位置显著相关（分别为P = 0.044和0.031）。多变量分析显示，年龄[风险比（HR）= 2.157，P = 0.008]、分期（HR = 2.234，P < 0.001）、切缘状态（HR = 2.748，P = 0.004）和TP表达（HR = 2.014，P = 0.039）与总生存期（OS）独立相关。
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