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伯纳德·勒勒:2014年首届全球组学与个性化医学沃纳·卡洛负责任创新奖获得者(环太平洋临床药物遗传学协会)

Bernard Lerer: recipient of the 2014 inaugural Werner Kalow Responsible Innovation Prize in Global Omics and Personalized Medicine (Pacific Rim Association for Clinical Pharmacogenetics).

作者信息

Ozdemir Vural, Endrenyi Laszlo, Aynacıoğlu Sükrü, Bragazzi Nicola Luigi, Dandara Collet, Dove Edward S, Ferguson Lynnette R, Geraci Christy Jo, Hafen Ernst, Kesim Belgin Eroğlu, Kolker Eugene, Lee Edmund J D, Llerena Adrian, Nacak Muradiye, Shimoda Kazutaka, Someya Toshiyuki, Srivastava Sanjeeva, Tomlinson Brian, Vayena Effy, Warnich Louise, Yaşar Umit

机构信息

1 Pacific Rim Association for Clinical Pharmacogenetics, Associate Member Society of the International Union of Basic and Clinical Pharmacology .

出版信息

OMICS. 2014 Apr;18(4):211-21. doi: 10.1089/omi.2014.0029. Epub 2014 Mar 20.

DOI:10.1089/omi.2014.0029
PMID:24649998
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3976589/
Abstract

This article announces the recipient of the 2014 inaugural Werner Kalow Responsible Innovation Prize in Global Omics and Personalized Medicine by the Pacific Rim Association for Clinical Pharmacogenetics (PRACP): Bernard Lerer, professor of psychiatry and director of the Biological Psychiatry Laboratory, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. The Werner Kalow Responsible Innovation Prize is given to an exceptional interdisciplinary scholar who has made highly innovative and enduring contributions to global omics science and personalized medicine, with both vertical and horizontal (transdisciplinary) impacts. The prize is established in memory of a beloved colleague, mentor, and friend, the late Professor Werner Kalow, who cultivated the idea and practice of pharmacogenetics in modern therapeutics commencing in the 1950s. PRACP, the prize's sponsor, is one of the longest standing learned societies in the Asia-Pacific region, and was founded by Kalow and colleagues more than two decades ago in the then-emerging field of pharmacogenetics. In announcing this inaugural prize and its winner, we seek to highlight the works of prize winner, Professor Lerer. Additionally, we contextualize the significance of the prize by recalling the life and works of Professor Kalow and providing a brief socio-technical history of the rise of pharmacogenetics and personalized medicine as a veritable form of 21(st) century scientific practice. The article also fills a void in previous social science analyses of pharmacogenetics, by bringing to the fore the works of Kalow from 1995 to 2008, when he presciently noted the rise of yet another field of postgenomics inquiry--pharmacoepigenetics--that railed against genetic determinism and underscored the temporal and spatial plasticity of genetic components of drug response, with invention of the repeated drug administration (RDA) method that estimates the dynamic heritabilities of drug response. The prize goes a long way to cultivate transgenerational capacity and broader cognizance of the concept and practice of responsible innovation as an important criterion of 21(st) century omics science and personalized medicine. A new call is presently in place for the 2016 PRACP Werner Kalow prize. Nominations can be made in support of an exceptional individual interdisciplinary scholar, or alternatively, an entire research team, from any region in the world with a record of highly innovative contributions to global omics science and/or personalized medicine, in the spirit of responsible innovation. The application process is straightforward, requiring a signed, 1500-word nomination letter (by the applicant or sponsor) submitted not later than May 31, 2015.

摘要

本文宣布了环太平洋临床药物遗传学协会(PRACP)颁发的2014年首届全球组学与个性化医学领域的维尔纳·卡洛负责任创新奖的获得者:伯纳德·勒雷尔,以色列耶路撒冷哈达萨-希伯来大学医学中心精神病学教授兼生物精神病学实验室主任。维尔纳·卡洛负责任创新奖授予一位杰出的跨学科科学家,他在全球组学科学和个性化医学领域做出了极具创新性和持久影响力的贡献,具有纵向和横向(跨学科)影响。该奖项是为了纪念一位深受爱戴的同事、导师和朋友——已故的维尔纳·卡洛教授而设立的,他从20世纪50年代开始在现代治疗学中培育药物遗传学的理念和实践。该奖项的主办方PRACP是亚太地区历史最悠久的学术团体之一,二十多年前由卡洛及其同事在当时新兴的药物遗传学领域创立。在宣布这一首届奖项及其获得者时,我们旨在突出获奖者勒雷尔教授的作品。此外,我们通过回顾卡洛教授的生平与作品,并简要介绍药物遗传学和个性化医学作为21世纪科学实践的一种切实形式兴起的社会技术历史,来阐述该奖项的重要意义。本文还填补了以往社会科学对药物遗传学分析的空白,重点介绍了卡洛在1995年至2008年期间的作品,当时他有先见之明地注意到后基因组学研究的另一个领域——药物表观遗传学的兴起,该领域反对基因决定论,并强调药物反应遗传成分的时空可塑性,同时发明了重复给药(RDA)方法来估计药物反应的动态遗传力。该奖项对于培养跨代能力以及更广泛地认识负责任创新的概念和实践大有帮助,而负责任创新是21世纪组学科学和个性化医学的一项重要标准。目前正在征集2016年PRACP维尔纳·卡洛奖的提名。提名可以支持一位杰出的跨学科科学家个人,或者一个来自世界任何地区、对全球组学科学和/或个性化医学有高度创新贡献记录的完整研究团队,提名需秉持负责任创新的精神。申请流程很简单,要求(申请人或主办方)在不迟于2015年5月31日提交一封1500字的签名提名信。

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