搭上精准医疗的列车：非遗传学家临床医生入门指南：第3部分。精准医疗领域的临床应用
Jumping on the Train of Personalized Medicine: A Primer for Non- Geneticist Clinicians: Part 3. Clinical Applications in the Personalized Medicine Area.
作者信息
Li Aihua, Meyre David
机构信息
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON L8N 3Z5, Canada.
出版信息
Curr Psychiatry Rev. 2014 May;10(2):118-132. doi: 10.2174/1573400510666140630170549.
Abstract
The rapid decline of sequencing costs brings hope that personal genome sequencing will become a common feature of medical practice. This series of three reviews aim to help non-geneticist clinicians to jump into the fast-moving field of personalized genetic medicine. In the first two articles, we covered the fundamental concepts of molecular genetics and the methodologies used in genetic epidemiology. In this third article, we discuss the evolution of personalized medicine and illustrate the most recent success in the fields of Mendelian and complex human diseases. We also address the challenges that currently limit the use of personalized medicine to its full potential.
摘要
测序成本的迅速下降带来了希望，即个人基因组测序将成为医疗实践的一个常见特征。这三篇综述系列旨在帮助非遗传学家临床医生投身于快速发展的个性化基因医学领域。在前两篇文章中，我们涵盖了分子遗传学的基本概念以及遗传流行病学中使用的方法。在这第三篇文章中，我们讨论了个性化医学的发展，并举例说明了孟德尔和复杂人类疾病领域的最新成功案例。我们还探讨了目前限制个性化医学充分发挥其潜力的挑战。
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