通过 N-[2-(1-炔基)苯基]碳二亚胺与异氰化物的碱促进串联反应合成吲哚基咪唑衍生物。
Synthesis of indolyl imidazole derivatives via base-promoted tandem reaction of N-[2-(1-alkynyl)phenyl]carbodiimides with isocyanides.
机构信息
College of Chemistry and Chemical Engineering, Jiangxi Normal University , Nanchang 330022, People's Republic of China.
出版信息
J Org Chem. 2014 Apr 18;79(8):3634-40. doi: 10.1021/jo402552c. Epub 2014 Mar 31.
PMID:24650146
Abstract
An efficient route to indolyl imidazole derivatives has been developed through a base-promoted tandem reaction of N-[2-(1-alkynyl)phenyl]carbodiimides with isocyanides in DMSO at 40 °C. The present tandem process allows the assembly of a variety of indolyl imidazole derivatives in moderate to good yields.
摘要
通过在 DMSO 中，在 40°C 下，N-[2-(1-炔基)苯基]碳二亚胺与异氰化物的碱促进串联反应，开发了一种高效的吲哚基咪唑衍生物的路线。本串联过程允许在中等至良好收率下组装各种吲哚基咪唑衍生物。
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