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I介导的Csp-P键形成：-炔基苯基异硫氰酸酯与有机磷酸酯的串联环化反应

I-mediated Csp-P bond formation tandem cyclization of -alkynylphenyl isothiocyanates with organophosphorus esters.

作者信息

Liu Yang, Wu Wenjin, Sang Xiaoyan, Xia Yu, Fang Guojian, Hao Wenyan

机构信息

College of Chemistry and Chemical Engineering, Jiangxi Normal University Nanchang 330022 People's Republic of China

出版信息

RSC Adv. 2022 Jun 20;12(28):18072-18076. doi: 10.1039/d2ra03072a. eCollection 2022 Jun 14.

DOI:10.1039/d2ra03072a
PMID:35800309
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9207709/
Abstract

A novel, I-mediated tandem cyclization of -alkynylphenyl isothiocyanates with organophosphorus esters has been developed under mild conditions. Different kinds of 4-benzo[][1,3]thiazin-2-ylphosphonate could be synthesized in moderate to excellent yields. This method has the advantages of easy access to raw materials, free-metal catalyst, simple operation, high yield and high functional group tolerance.

摘要

在温和条件下，已开发出一种新颖的、碘介导的异硫氰酸 - 炔基苯基酯与有机磷酸酯的串联环化反应。可以以中等至优异的产率合成不同种类的4 - 苯并[][1,3]噻嗪 - 2 - 基膦酸酯。该方法具有原料易得、无金属催化剂、操作简单、产率高和官能团耐受性强等优点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d8f/9207709/1dfdfe2eed86/d2ra03072a-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d8f/9207709/393c0c0b3470/d2ra03072a-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d8f/9207709/e9ef43ca498d/d2ra03072a-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d8f/9207709/9eef1c4879ed/d2ra03072a-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d8f/9207709/1dfdfe2eed86/d2ra03072a-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d8f/9207709/393c0c0b3470/d2ra03072a-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d8f/9207709/e9ef43ca498d/d2ra03072a-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d8f/9207709/9eef1c4879ed/d2ra03072a-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d8f/9207709/1dfdfe2eed86/d2ra03072a-s4.jpg

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本文引用的文献

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2
Cobalt Catalyzed C-P Bond Formation by Cross-Coupling of Boronic Acids with P(O)H Compounds in Presence of Zinc.钴催化硼酸与 P(O)H 化合物在锌存在下的交叉偶联形成 C-P 键。
Molecules. 2020 Jan 10;25(2):290. doi: 10.3390/molecules25020290.
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Recent advances in phosphine catalysis involving γ-substituted allenoates.
涉及 γ-取代丙二烯酸酯的膦催化的最新进展。
Chem Commun (Camb). 2020 Jan 16;56(5):680-694. doi: 10.1039/c9cc08241g.
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Catalyst-free phosphorylation of aryl halides with trialkyl phosphites through electrochemical reduction.通过电化学还原实现三烷基膦与芳基卤化物的无催化剂磷酸化反应。
Chem Commun (Camb). 2019 Nov 19;55(93):14035-14038. doi: 10.1039/c9cc07069a.
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Nickel-Catalyzed Electrochemical Phosphorylation of Aryl Bromides.镍催化的芳基溴的电化学磷酸化。
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