Kardum Nevena, Konić-Ristić Aleksandra, Savikin Katarina, Spasić Slavica, Stefanović Aleksandra, Ivanišević Jasmina, Miljković Milica
1 Center of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade , Belgrade, Serbia .
J Med Food. 2014 Aug;17(8):869-74. doi: 10.1089/jmf.2013.0135. Epub 2014 Mar 20.
Berry fruits are a rich source of polyphenols, especially anthocyanins: well-known potent anti-oxidant phytochemicals. The purpose of this study was to evaluate beneficial effects of long-term consumption of polyphenol-rich organic chokeberry juice on different markers of antioxidant/pro-oxidant status in healthy female volunteers. Twenty-nine women, aged 25-49, were included in the study. Serological markers of oxidative stress and antioxidant defence, blood pressure, routine biochemical, and anthropometric parameters were analyzed at baseline and after twelve weeks of regular chokeberry juice consumption. Significant decrease in thiobarbituric acid-reactive substances level (TBARS; P<.001) and pro-oxidant-antioxidant balance (PAB; P<.05), as well as increase in paroxonase-1 activity toward diazoxon (P<.01) were found. Total oxidative status and sulphydryl groups levels were not significantly influenced by the intervention. Anthropometric, biochemical parameters, and blood pressure values were within the referent values for all subjects and were not influenced by the chokeberry juice consumption. However, we found positive correlation between age, body mass index, waist circumference, body fat percent, blood pressure, and analyzed marker of lipid peroxidation, which was influenced by the consumption. In conclusion, the fine modulation of several antioxidant/pro-oxidant status biomarkers observed in healthy subjects indicates putative prophylactic effects of polyphenol-rich chokeberry juice and supports its importance as part of an optimal diet.
浆果类水果富含多酚，尤其是花青素：它们是众所周知的强效抗氧化植物化学物质。本研究的目的是评估长期饮用富含多酚的有机黑果腺肋花楸汁对健康女性志愿者抗氧化/促氧化状态不同指标的有益影响。29名年龄在25至49岁之间的女性被纳入该研究。在基线时以及在定期饮用黑果腺肋花楸汁12周后，分析了氧化应激和抗氧化防御的血清学指标、血压、常规生化指标以及人体测量参数。发现硫代巴比妥酸反应性物质水平（TBARS；P<0.001）和促氧化-抗氧化平衡（PAB；P<0.05）显著降低，以及对重氮磷酯酶-1对二氮嗪的活性增加（P<0.01）。总氧化状态和巯基水平未受到干预的显著影响。所有受试者的人体测量、生化参数和血压值均在参考值范围内，且未受到饮用黑果腺肋花楸汁的影响。然而，我们发现年龄、体重指数、腰围、体脂百分比、血压与所分析的脂质过氧化指标之间存在正相关，而饮用黑果腺肋花楸汁对其有影响。总之，在健康受试者中观察到的几种抗氧化/促氧化状态生物标志物的精细调节表明富含多酚的黑果腺肋花楸汁具有潜在的预防作用，并支持其作为最佳饮食一部分的重要性。
