Manikas Anastasios C, Romeo Giovanni, Papa Antonio, Netti Paolo A
Center for Advanced Biomaterials for Healthcare @CRIB, Istituto Italiano di Tecnologia (IIT) , Largo Barsanti e Matteucci 53, 80125 Naples, Italy.
Langmuir. 2014 Apr 8;30(13):3869-75. doi: 10.1021/la4048616. Epub 2014 Mar 28.
Employing thermoresponsive hydrogels as scaffolding material for noble metal surface loading might be useful for the fabrication of surface-enhanced Raman scattering (SERS) surfaces. Here, we report on a new, reproducible, and simple approach to engineer poly(N-isopropylacrylamide) (PNIPAAm) hydrogel surfaces optimized for physisorption of gold nanoparticles (AuNPs). The advantage of this approach consists of the simple mechanism by which AuNPs are adsorbed on hydrogel templates, without sophisticated chemical treatments for their conjugation with the hydrogel. The resulting PNIPAAm-40 nm AuNP modes demonstrate that this approach gives the capability to tune the interparticle distance and, therefore, to control and modulate SERS affinity upon temperature changing.
使用热响应水凝胶作为贵金属表面负载的支架材料可能有助于制造表面增强拉曼散射（SERS）表面。在此，我们报告一种新的、可重复且简单的方法，用于设计经优化以实现金纳米颗粒（AuNP）物理吸附的聚（N-异丙基丙烯酰胺）（PNIPAAm）水凝胶表面。该方法的优势在于AuNP吸附在水凝胶模板上的机制简单，无需对其与水凝胶的结合进行复杂的化学处理。所得的PNIPAAm-40 nm AuNP模式表明，这种方法能够调节颗粒间距离，从而在温度变化时控制和调节SERS亲和力。
