Lipman Grant S, Krabak Brian J, Waite Brandee L, Logan Sarah B, Menon Anil, Chan Garrett K
a Stanford University School of Medicine, Surgery , Stanford , CA , USA.
Res Sports Med. 2014;22(2):185-92. doi: 10.1080/15438627.2014.881824.
The purpose of the study was to evaluate the prevalence of acute kidney injury (AKI) during a multi-stage ultramarathon foot race. A prospective observational study was taken during the Gobi 2008; Sahara 2008; and Namibia 2009 RacingThePlanet 7-day, 6-stage, 150-mile foot ultramarathons. Blood was analyzed before, and immediately after stage 1 (25 miles), 3 (75 miles), and 5 (140 miles). Creatinine (Cr), glomerular filtration rate (GFR), and incidence of AKI were calculated and defined by RIFLE criteria. Thirty participants (76% male, mean age 40 + 11 years) were enrolled. There were significant declines in GFR after each stage compared with the pre-race baseline (p < 0.001), with the majority of participants (55-80%) incurring AKI. The majority of study participants encountered significant renal impairment; however, no apparent cumulative effect was observed, with resolution of renal function to near baseline levels between stages.
本研究的目的是评估在一场多阶段超级马拉松赛跑中急性肾损伤（AKI）的发生率。在2008年戈壁、2008年撒哈拉和2009年纳米比亚“挑战地球”7天6阶段150英里超级马拉松赛跑期间进行了一项前瞻性观察研究。在第1阶段（25英里）、第3阶段（75英里）和第5阶段（140英里）之前及之后立即对血液进行分析。根据RIFLE标准计算并定义肌酐（Cr）、肾小球滤过率（GFR）和AKI的发生率。招募了30名参与者（76%为男性，平均年龄40±11岁）。与赛前基线相比，每个阶段后的GFR均显著下降（p<0.001），大多数参与者（55%-80%）发生了AKI。大多数研究参与者出现了明显的肾功能损害；然而，未观察到明显的累积效应，各阶段之间肾功能恢复到接近基线水平。
