Chang Wei-Kuo, Lin Hsuan-Hwai, Hsieh Tsai-Yuan, Ou Tzu-Ming, Chen Hsuan-Wei
Division of Gastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taiwan.
Division of Gastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taiwan.
Med Hypotheses. 2014 Jun;82(6):678-80. doi: 10.1016/j.mehy.2014.03.002. Epub 2014 Mar 12.
Percutaneous endoscopic gastrostomy (PEG) is a well-established enteral feeding modality in patients with oropharyngeal/esophageal cancer; however, these patients are at risk for two possible PEG-related complications. First, oropharyngeal organisms may be transported to the PEG stoma and thus increase the risk of peristomal infection. Second, oropharyngeal/esophageal cancer cells may adhere to the PEG tube and thus increase the risk of tumor seeding along the PEG tract. Because of its microbicidal and tumoricidal effects, povidone-iodine pretreatment of the PEG tube may decrease the risk of peristomal infection and tumor seeding associated with PEG insertion in patients with oropharyngeal/esophageal cancer. To test this hypothesis, we brushed povidone-iodine onto the outer surface of PEG tubes prior to insertion.
经皮内镜下胃造口术（PEG）是口咽/食管癌患者中一种成熟的肠内营养方式；然而，这些患者存在两种可能与PEG相关的并发症风险。首先，口咽微生物可能被输送至PEG造口，从而增加造口周围感染的风险。其次，口咽/食管癌细胞可能附着于PEG管，从而增加肿瘤沿PEG通道种植的风险。由于聚维酮碘具有杀菌和杀肿瘤细胞的作用，对PEG管进行聚维酮碘预处理可能会降低口咽/食管癌患者PEG置入相关的造口周围感染和肿瘤种植风险。为验证这一假设，我们在PEG管插入前将聚维酮碘刷涂在其外表面。
