Allergy and Immunology Division, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas.
The Cooper Institute, Dallas, Texas.
Ann Allergy Asthma Immunol. 2014 May;112(5):432-6. doi: 10.1016/j.anai.2014.02.015. Epub 2014 Mar 18.
Prior research suggests a possible association between asthma and depression.
To examine the association between asthma and depressive symptoms, controlling for asthma medications, lung function, and overall health.
We conducted a cross-sectional study of 12,944 adults who completed physician-based preventive health examinations at the Cooper Clinic from 2000 to 2012. Information on medical histories, including asthma and depression, and medications were collected. Participants reported overall health status, completed spirometry testing, and underwent depression screening using the 10-item Center for Epidemiologic Studies Depression Scale (CES-D). Dependent variables of current depressive symptoms (CES-D scores ≥10) and lifetime history of depression were separately modeled using logistic regression with independent variables, including demographics, spirometry, asthma controller medications, and patient-reported health status.
The sample was predominantly white and well educated. The prevalence of asthma was 9.0%. Asthma was associated with an odds ratio (OR) of 1.41 (95% CI, 1.16-1.70; P < .001) of current depressive symptoms based on CES-D score. Asthma was also associated with lifetime history of depression (OR, 1.66; 95% CI, 1.40-1.95; P < .001). Neither lung function nor asthma controller medications were significantly associated with depression.
Asthma was associated with increased prevalence of current depressive symptoms and lifetime depression in a large sample of relatively healthy adults. These findings suggest that the increased likelihood of depression among patients with asthma does not appear to be exclusively related to severe or poorly controlled asthma. People with asthma, regardless of severity, may benefit from depression screening in clinical settings.
先前的研究表明哮喘和抑郁之间可能存在关联。
在控制哮喘药物、肺功能和整体健康状况的情况下，研究哮喘与抑郁症状之间的关联。
我们对 2000 年至 2012 年间在库珀诊所接受过基于医生的预防性健康检查的 12944 名成年人进行了一项横断面研究。收集了包括哮喘和抑郁在内的病史信息以及药物使用情况。参与者报告了整体健康状况，完成了肺活量测试，并使用 10 项流行病学研究中心抑郁量表（CES-D）进行了抑郁筛查。使用逻辑回归模型，以包括人口统计学、肺活量、哮喘控制药物和患者报告的健康状况在内的独立变量，分别对当前抑郁症状（CES-D 评分≥10）和终生抑郁史的因变量进行建模。
样本主要为白人且受教育程度较高。哮喘的患病率为 9.0%。基于 CES-D 评分，哮喘与当前抑郁症状的比值比（OR）为 1.41（95% CI，1.16-1.70；P<0.001）。哮喘还与终生抑郁史相关（OR，1.66；95% CI，1.40-1.95；P<0.001）。肺功能和哮喘控制药物均与抑郁无显著相关性。
在一个相对健康的成年人的大样本中，哮喘与当前抑郁症状和终生抑郁的患病率增加相关。这些发现表明，哮喘患者中抑郁的可能性增加似乎并非完全与严重或控制不佳的哮喘有关。无论哮喘严重程度如何，患有哮喘的人可能会受益于临床环境中的抑郁筛查。
