抑制性中间神经元的内源性大麻素信号转导。
Endogenous cannabinoid signaling at inhibitory interneurons.
机构信息
Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, United States.
Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, United States.
出版信息
Curr Opin Neurobiol. 2014 Jun;26:42-50. doi: 10.1016/j.conb.2013.12.006. Epub 2013 Dec 28.
Abstract
Significant progress has been made in our understanding of how endogenous cannabinoids (eCBs) signal at excitatory and inhibitory synapses in the central nervous system (CNS). This review discusses how eCBs regulate inhibitory interneurons, their synapses, and the networks in which they are embedded. eCB signaling plays a pivotal role in brain physiology by means of their synaptic signal transduction, spatiotemporal signaling profile, routing of information through inhibitory microcircuits, and experience-dependent plasticity. Understanding the normal processes underlying eCB signaling is beginning to shed light on how their dysregulation contributes to disease.
摘要
我们对中枢神经系统（CNS）中内源性大麻素（eCB）在兴奋性和抑制性突触处的信号传递有了更深入的了解。这篇综述讨论了 eCB 如何调节抑制性中间神经元及其突触，以及它们所处的网络。通过其突触信号转导、时空信号特征、通过抑制性微电路传递信息的路由以及经验依赖性可塑性，eCB 信号转导在大脑生理学中起着关键作用。了解 eCB 信号转导的正常过程开始揭示其失调如何导致疾病。
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