既往患恶性肿瘤后发生肺癌的特征。

Characteristics of lung cancer after a previous malignancy.

作者信息

Reinmuth Niels, Stumpf Patrick, Stumpf Andreas, Muley Thomas, Kobinger Sonja, Hoffmann Hans, Herth Felix J F, Schnabel Philipp A, Bischoff Helge, Thomas Michael

机构信息

Department of Thoracic Oncology, Thoraxklinik at the University of Heidelberg, 69126 Heidelberg, Germany; Translational Lung Research Center Heidelberg, German Center for Lung Research, Germany.

Department of Thoracic Oncology, Thoraxklinik at the University of Heidelberg, 69126 Heidelberg, Germany.

出版信息

Respir Med. 2014 Jun;108(6):910-7. doi: 10.1016/j.rmed.2014.02.015. Epub 2014 Mar 5.

DOI:10.1016/j.rmed.2014.02.015

PMID:24650574

Abstract

BACKGROUND

In the era of improving overall survival rates of malignant diseases, the impact of a previous malignancy (PM) on treatment and outcome of lung cancer (LC) remains unclear.

METHODS

We reviewed all LC patients from our institution that were treated from 2004 to 2006 for the occurrence of LC with PM excluding patients with multiple primary LC.

RESULTS

A total of 444 and 2698 LC patients with and without a history of a PM were identified (prevalence of 14.1%). PM were most often located in breast (15.5%), prostate (14.9%), bladder (9.0%) and kidney (8.8%). Compared to never smokers, patients with nicotine consumption had more often a cancer history of prostate, gastrointestinal, and the head-neck region. The median interval until diagnosis of LC was 72.2 months (range 0-537 months) with most LC diagnosed 5 years after PM diagnosis. With a similar distribution of histology, stage and localization compared to controls, NSCLC patients with PM and stage IV disease showed a favorable overall survival (p < 0.0001). In contrast, SCLC patients had similar survival curves (n.s.).

CONCLUSIONS

A considerable subgroup of LC patients has a history of PM that may indicate a favorable prognostic factor. However, these patients should be treated similar to other LC patients.

摘要

背景

在恶性疾病总体生存率不断提高的时代，既往恶性肿瘤（PM）对肺癌（LC）治疗及预后的影响仍不明确。

方法

我们回顾了我院2004年至2006年期间接受治疗的所有LC患者，这些患者因LC伴PM发病，不包括多原发性LC患者。

结果

共识别出444例有PM病史的LC患者和2698例无PM病史的LC患者（患病率为14.1%）。PM最常发生于乳腺（15.5%）、前列腺（14.9%）、膀胱（9.0%）和肾脏（8.8%）。与从不吸烟者相比，有尼古丁消费史的患者更常患有前列腺、胃肠道和头颈部癌症病史。直至诊断为LC的中位间隔时间为72.2个月（范围0 - 537个月），大多数LC在PM诊断后5年被诊断。与对照组相比，组织学、分期和定位分布相似，有PM且处于IV期疾病的非小细胞肺癌患者总体生存率良好（p < 0.0001）。相比之下，小细胞肺癌患者的生存曲线相似（无统计学差异）。