去氧肾上腺素可降低额皮质组织氧合的空间分辨近红外光谱测定值，反映皮肤血流量减少。
A decrease in spatially resolved near-infrared spectroscopy-determined frontal lobe tissue oxygenation by phenylephrine reflects reduced skin blood flow.
机构信息
From the *Department of Biomedical Engineering, Toyo University, Kawagoe-Shi, Saitama; †Research Institute of Physical Fitness, Japan Women's College of Physical Education, Tokyo; ‡Department of Environmental Physiology for Exercise, Osaka City University Graduate School of Medicine; §Faculty of Health Sciences, Morinomiya University of Medical Sciences, Osaka, Japan; ‖Department of Anesthesia, The Copenhagen Muscle Research Center, University of Copenhagen, Copenhagen, Denmark; and ¶Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
出版信息
Anesth Analg. 2014 Apr;118(4):823-9. doi: 10.1213/ANE.0000000000000145.
BACKGROUND
Spatially resolved near-infrared spectroscopy-determined frontal lobe tissue oxygenation (ScO2) is reduced with administration of phenylephrine, while cerebral blood flow may remain unaffected. We hypothesized that extracranial vasoconstriction explains the effect of phenylephrine on ScO2.
METHODS
We measured ScO2 and internal and external carotid as well as vertebral artery blood flow in 7 volunteers (25 [SD 4] years) by duplex ultrasonography during IV infusion of phenylephrine, together with middle cerebral artery mean blood velocity, forehead skin blood flow, and mean arterial blood pressure.
RESULTS
During phenylephrine infusion, mean arterial blood pressure increased, while ScO2 decreased by -19% ± 3% (mean ± SE; P = 0.0005). External carotid artery (-27.5% ± 3.0%) and skin blood flow (-25.4% ± 7.8%) decreased in response to phenylephrine administration, and there was a relationship between ScO2 and forehead skin blood flow (Pearson r = 0.55, P = 0.042, 95% confidence interval [CI], = 0.025-0.84; Spearman r = 0.81, P < 0.001, 95% CI, 0.49-0.94) and external carotid artery conductance (Pearson r = 0.62, P = 0.019, 95% CI, 0.13 to 0.86; Spearman r = 0.64, P = 0.012, 95% CI, 0.17-0.88).
CONCLUSIONS
These findings suggest that a phenylephrine-induced decrease in ScO2, as determined by INVOS-4100 near-infrared spectroscopy, reflects vasoconstriction in the extracranial vasculature rather than a decrease in cerebral oxygenation.
背景
使用 INVOS-4100 近红外光谱仪测定，去氧肾上腺素给药后额皮质组织氧饱和度（ScO2）降低，而脑血流可能不受影响。我们假设，颅外血管收缩解释了去氧肾上腺素对 ScO2 的影响。
方法
我们通过双功能超声测量了 7 名志愿者（25 [SD 4] 岁）在静脉注射去氧肾上腺素时的 ScO2 以及颈内、颈外和椎动脉血流，同时还测量了大脑中动脉平均血流速度、额部皮肤血流和平均动脉血压。
结果
去氧肾上腺素输注期间，平均动脉血压升高，而 ScO2 降低 19%±3%（平均值±SE；P=0.0005）。颈外动脉（-27.5%±3.0%）和皮肤血流（-25.4%±7.8%）对去氧肾上腺素给药有反应，ScO2 与额部皮肤血流（Pearson r=0.55，P=0.042，95%置信区间[CI]，0.025-0.84；Spearman r=0.81，P＜0.001，95% CI，0.49-0.94）和颈外动脉传导性（Pearson r=0.62，P=0.019，95% CI，0.13-0.86；Spearman r=0.64，P=0.012，95% CI，0.17-0.88）之间存在相关性。
结论
这些发现表明，INVOS-4100 近红外光谱仪测定的去氧肾上腺素引起的 ScO2 降低反映了颅外血管收缩，而不是脑氧合降低。
Zotero 插件