Vinazzer H
Coagulation Laboratory, Linz, Austria.
Folia Haematol Int Mag Klin Morphol Blutforsch. 1988;115(3):253-9.
A series of coagulation tests is described by which an increased thrombotic tendency is likely to be detected. These tests were carried out in 268 patients with venous thromboembolic disease and in 583 patients with arterial thrombotic manifestations. In venous thromboembolism alterations which point to hypercoagulability were found in 50% of all cases. Most frequent findings were a diminished availability of t-PA followed by low levels of Protein C, AT III and of Heparin cofactor II. In arterial thrombotic disease alterations of the clotting system were found in 77% of the patients. There was a high frequency of increased spontaneous platelet aggregation, of a diminished t-PA availability and of a combination of both alterations. Other abnormal results were rare with the exception of a diminished Heparin cofactor II which was found in 3% of the patients. The consequences which arise for prophylaxis and therapy when the defect is known are discussed.
本文描述了一系列凝血试验，通过这些试验有可能检测到血栓形成倾向增加。对268例静脉血栓栓塞性疾病患者和583例有动脉血栓形成表现的患者进行了这些试验。在静脉血栓栓塞症中，50%的病例发现了提示高凝状态的改变。最常见的发现是组织型纤溶酶原激活物（t-PA）可用性降低，其次是蛋白C、抗凝血酶III（AT III）和肝素辅因子II水平较低。在动脉血栓形成疾病中，77%的患者发现了凝血系统改变。自发性血小板聚集增加、t-PA可用性降低以及两者兼有的情况很常见。除了3%的患者发现肝素辅因子II降低外，其他异常结果很少见。文中讨论了已知缺陷时对预防和治疗的影响。
