Pál A, Sas G
Orvostovábbképzö Egyetem, I. sz. Belgyógyászati Klinika, Budapest.
Orv Hetil. 1990 Mar 4;131(9):461-2, 465.
The plasma concentration of heparin cofactor II was measured by "rocket" immunoelectrophoresis in healthy volunteers, patients taking Syncumar and thrombophiliacs. The values in healthy volunteers averaged 99% (+/- 16.5). In the group of Syncumar treated patients 100% (+/- 10.5) was measured. This did not differ from the control group. The average of heparin cofactor II level in thrombophiliacs was 92.5% (+/- 23). In this group three patients had low heparin cofactor II levels. In one case this was due to intestinal protein loss. In the two other cases the role of heparin cofactor II is uncertain in the pathogenesis of thrombophilia.
采用“火箭”免疫电泳法测定了健康志愿者、服用香豆素的患者以及血栓形成倾向者体内肝素辅因子II的血浆浓度。健康志愿者体内的值平均为99%（±16.5）。在服用香豆素的患者组中测得的值为100%（±10.5）。这与对照组没有差异。血栓形成倾向者体内肝素辅因子II水平的平均值为92.5%（±23）。该组中有3名患者的肝素辅因子II水平较低。其中1例是由于肠道蛋白质丢失所致。在另外2例中，肝素辅因子II在血栓形成倾向发病机制中的作用尚不确定。
