Leipnitz G, Jung F, Lawall H, Kiesewetter H, Knoop U, Schöneberger H J, Frank M, Hellstern P, Sitzmann F C, Wenzel E
Department of Clinical Hemostaseology and Transfusion Medicine, University of Saarland, Homburg/Saar, FRG.
Folia Haematol Int Mag Klin Morphol Blutforsch. 1988;115(3):366-70.
In a three-year bicentric cross-sectional investigation on type I diabetic children between six and eighteen years of age, blood sugar profiles and spontaneous thrombocyte aggregation were assessed besides anamnestic and clinical data. In the children treated with human insulin raised spontaneous thrombocyte aggregation was significantly more frequent than in those treated with porcine insulin. At the same time blood sugar fluctuation from day to day measured between seven and nine a.m. tended to be raised in the children treated with human insulin; the fluctuation in the diurnal profile measured for fourteen days was indeed very much greater. Since the two groups were comparable as to sex distribution, age, duration of disease, quality of compensation, application and dose of insulin, the greater fluctuation of blood sugar in the children treated with human insulin appears to be the cause for the raised spontaneous thrombocyte aggregation.
在一项针对6至18岁I型糖尿病儿童的为期三年的双中心横断面调查中，除了收集既往病史和临床数据外，还评估了血糖状况和自发性血小板聚集情况。接受人胰岛素治疗的儿童中，自发性血小板聚集增加的情况明显比接受猪胰岛素治疗的儿童更常见。与此同时，上午7点至9点测得的接受人胰岛素治疗的儿童的每日血糖波动往往更大；连续14天测得的昼夜血糖波动情况确实要大得多。由于两组在性别分布、年龄、病程、代偿质量、胰岛素的使用和剂量方面具有可比性，因此接受人胰岛素治疗的儿童血糖波动较大似乎是自发性血小板聚集增加的原因。
