Shukla A, Agarwal K N, Chansuria J P, Taneja V
Department of Paediatrics, Banaras Hindu University, Varanasi, India.
J Neurochem. 1989 Mar;52(3):730-5. doi: 10.1111/j.1471-4159.1989.tb02515.x.
Eight weeks of latent iron deficiency in weaned rats maintained on an experimental low iron content diet (18-20 mg/kg) did not significantly alter the packed cell volume and hemoglobin concentration; however, the hepatic and brain nonheme iron contents decreased by 66% and 21% (p less than 0.001), respectively. The tryptophan concentration decreased by 31% and 34% in liver and brain, respectively, in rats on experimental diet (p less than 0.01). The brain 5-hydroxytryptamine and 5-hydroxyindoleacetic acid contents were reduced by 21% and 23% (p less than 0.01 and p less than 0.02), respectively. However, in the brain, weight, protein, DNA, and the activities of monoamine oxidase, aldehyde dehydrogenase, and liver tryptophan oxygenase were found to remain unaltered. When rehabilitated with a diet containing 390 mg/kg iron, rats previously maintained on the experimental diet for 2 weeks showed partial recovery in tryptophan levels both in liver and brain. However, brain 5-hydroxytryptamine and 5-hydroxyindoleacetic acid levels remained unaltered. The hepatic iron content improved without any change in brain iron content. The latent iron deficiency produced significant alterations in the metabolism of 5-hydroxytryptamine and brain iron content that could not be recovered 2 weeks after the iron rehabilitation.
以低铁含量（18 - 20毫克/千克）实验性饮食喂养的断奶大鼠，8周的潜在缺铁状态并未显著改变红细胞压积和血红蛋白浓度；然而，肝脏和脑非血红素铁含量分别下降了66%和21%（p < 0.001）。实验饮食组大鼠肝脏和脑中色氨酸浓度分别下降了31%和34%（p < 0.01）。脑5-羟色胺和5-羟吲哚乙酸含量分别降低了21%和23%（p < 0.01和p < 0.02）。然而，在脑中，重量、蛋白质、DNA以及单胺氧化酶、醛脱氢酶和肝脏色氨酸加氧酶的活性均未改变。当用含铁390毫克/千克的饮食进行恢复治疗时，先前以实验饮食喂养2周的大鼠肝脏和脑中色氨酸水平出现部分恢复。然而，脑5-羟色胺和5-羟吲哚乙酸水平仍未改变。肝脏铁含量有所改善，而脑铁含量无变化。潜在缺铁对5-羟色胺代谢和脑铁含量产生了显著改变，且在铁恢复治疗2周后仍未恢复。
