Park Dong Choon, Yeo Seung Geun
Department of Obstetrics and Gynecology, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea.
Department of Otolaryngology, College of Medicine, KyungHee University, Seoul, Korea.
Korean J Audiol. 2013 Sep;17(2):39-44. doi: 10.7874/kja.2013.17.2.39. Epub 2013 Sep 24.
Aging is initiated based on genetic and environmental factors that operate from the time of birth of organisms. Aging induces physiological phenomena such as reduction of cell counts, deterioration of tissue proteins, tissue atrophy, a decrease of the metabolic rate, reduction of body fluids, and calcium metabolism abnormalities, with final progression onto pathological aging. Despite the efforts from many researchers, the progression and the mechanisms of aging are not clearly understood yet. Therefore, the authors would like to introduce several theories which have gained attentions among the published theories up to date; genetic program theory, wear-and-tear theory, telomere theory, endocrine theory, DNA damage hypothesis, error catastrophe theory, the rate of living theory, mitochondrial theory, and free radical theory. Although there have been many studies that have tried to prevent aging and prolong life, here we introduce a couple of theories which have been proven more or less; food, exercise, and diet restriction.
衰老基于从生物体出生时起就起作用的遗传和环境因素而开始。衰老会引发诸如细胞数量减少、组织蛋白退化、组织萎缩、代谢率降低、体液减少以及钙代谢异常等生理现象,最终发展为病理性衰老。尽管众多研究人员付出了努力,但衰老的进程和机制仍未被清楚地理解。因此,作者想介绍几种在迄今为止已发表的理论中受到关注的理论;遗传程序理论、磨损理论、端粒理论、内分泌理论、DNA损伤假说、错误灾难理论、生活速率理论、线粒体理论和自由基理论。尽管有许多研究试图预防衰老和延长寿命,但在此我们介绍几种已或多或少得到证实的理论;食物、运动和饮食限制。