Department of Toxicology, Faculty of Pharmacy, Gazi University, Ankara, Turkey.
Department of General Surgery, Faculty of Medicine, Gazi University, Ankara, Turkey.
Adv Exp Med Biol. 2021;1275:35-69. doi: 10.1007/978-3-030-49844-3_2.
Recently, aging has been tried to be explained with large numbers of theories, but none of them can elucidate the changes occurring in the aging process alone. A unified theory encompassing the mechanisms of genetic factors and repair systems in aging is becoming increasingly required. Almost 37 protein kinases contribute to all processes of aging and senescence. Furthermore, these kinases not only regulate the large number of metabolic pathways related to aging processes, but also control these pathways through 12 checkpoints. Thus, in this chapter, the metabolic targets of protein kinases signal transduction pathways were discussed in terms of the aging perspective under five headings, which are the indispensable stages of the aging process. Although the most popular classical aging theories have been stated as DNA damage theory, mitochondrial theory, free radical theory, and telomere theory, it was concluded that the aging process is controlled by protein kinases regardless of the different theories.
最近，人们尝试用大量理论来解释衰老，但没有一种理论能够单独阐明衰老过程中发生的变化。因此，人们越来越需要一种包含遗传因素和修复系统机制的统一理论。几乎有 37 种蛋白激酶参与衰老和衰老的所有过程。此外，这些激酶不仅调节与衰老过程相关的大量代谢途径，而且还通过 12 个检查点控制这些途径。因此，在这一章中，从衰老的角度讨论了蛋白激酶信号转导途径的代谢靶标，分为五个标题，这些标题是衰老过程中不可缺少的阶段。尽管最流行的经典衰老理论被表述为 DNA 损伤理论、线粒体理论、自由基理论和端粒理论，但无论理论如何，都可以得出结论，衰老过程受蛋白激酶控制。
