Yuan Ye, Duff Michelle L, Sammons Dawn L, Wu Shiyong
Ye Yuan, Shiyong Wu, Edison Biotechnology Institute and Department of Chemistry and Biochemistry, Ohio University, Athens, OH 45701, United States.
World J Clin Cases. 2014 Mar 16;2(3):52-6. doi: 10.12998/wjcc.v2.i3.52.
To investigate cancer cell absence or presence in wide excision after biopsy of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) patients.
200 patients (100 BCC and 100 SCC) from the same dermatology clinic, who had positive margin upon biopsy, were selected from a computer generated randomized report. All selected patients had wide excision following biopsy. To determine the correlation of gender, age distribution and cancer absence, BCC and SCC cases were separated based on excision-cancer absent or present after wide excision. χ(2) tests, Fisher's exact tests were used to analyze the ratio of male to female between excision-cancer absent and excision-cancer present patients, while Mann-Whitney U test were used to compare the age distribution in the two groups. Statistical analyses were performed using SPSS version 16.0 for Windows.
Our retrospective chart review of the patients showed that cancer cells were absent in 49% of BCC patients (n = 100) and 64% of SCC patients (n = 100) who had previously had positive margins upon biopsy. Gender analysis showed the ratio of male to female (M/F) in the BCC arm was significantly higher compared with the SCC arm in those with excision-cancer absent (2.06 vs 0.66; P = 0.004; χ(2) test). But M/F of excision-cancer absent and excision-cancer present in neither BCC nor SCC patients was statistically significant. Age adjustment showed no significant difference between excision-cancer absent and excision-cancer present in BCC and SCC patients. Nevertheless, in excision-cancer absent cases, the age distribution showed that the BCC patients were younger than SCC patients (average age 67 vs 74; P < 0.001; Mann-Whitney U test). In addition, our data also indicated that in the patient group of 71-80 years old, there were more SCC patients who showed excision-cancer absence (67.6% vs 39.4%; P = 0.02; χ(2) test).
Our study indicates that approximately 50% or more of BCC and SCC patients with positive margins found on biopsies did not have cancer cells present at the time of wide excisions.
调查鳞状细胞癌（SCC）和基底细胞癌（BCC）患者活检后广泛切除标本中癌细胞的有无情况。
从同一皮肤科诊所的计算机生成随机报告中选取200例患者（100例BCC和100例SCC），这些患者活检切缘阳性。所有入选患者活检后均进行了广泛切除。为确定性别、年龄分布与癌症有无的相关性，根据广泛切除后有无癌细胞将BCC和SCC病例分开。采用χ²检验、Fisher精确检验分析广泛切除后无癌与有癌患者的男女比例，同时采用Mann-Whitney U检验比较两组的年龄分布。使用SPSS 16.0 for Windows进行统计分析。
我们对患者的回顾性病历审查显示，先前活检切缘阳性的BCC患者（n = 100）中有49%以及SCC患者（n = 100）中有64%的标本中未发现癌细胞。性别分析显示，在广泛切除后无癌的患者中，BCC组的男女比例（M/F）显著高于SCC组（2.06 vs 0.66；P = 0.004；χ²检验）。但在BCC和SCC患者中，广泛切除后无癌与有癌的M/F均无统计学意义。年龄校正显示，BCC和SCC患者中广泛切除后无癌与有癌之间无显著差异。然而，在广泛切除后无癌的病例中，年龄分布显示BCC患者比SCC患者年轻（平均年龄分别为67岁和74岁；P < 0.001；Mann-Whitney U检验）。此外，我们的数据还表明，在71 - 80岁的患者组中，显示广泛切除后无癌的SCC患者更多（67.6% vs 39.4%；P = 0.02；χ²检验）。
我们的研究表明，活检切缘阳性的BCC和SCC患者中，约50%或更多在广泛切除时不存在癌细胞。
