Healy D, English F, Daniels A, Ryan C A
Ir Med J. 2014 Feb;107(2):46.
Neonatal abstinence syndrome (NAS) is the clinical picture of infants withdrawing from in-utero substance exposure. The incidence of NAS rose in Dublin maternity hospitals in the 1970's and '80's in parallel with increasing in opiate abuse in that city. The purpose of this study was to determine if a similar pattern was emerging in Cork University Maternity Hospital. Data from the Erinville Hospital (2000-2007) and CUMH (2008-2011) were compared. Sixteen cases of NAS were identified, two at Erinville Hospital (22,987 deliveries; incidence = 0.09/1000 deliveries) and 14 at CUMH (37,414 deliveries; incidence = 0.38/1000 deliveries; p < 0.01). Five of the 16 mothers were using heroin, while ten were on methadone maintenance. All were multi-drug abusers. Newborns requiring pharmacotherapy for NAS (5/16) had prolonged hospitalisations compared to those requiring supportive care. NAS in Cork is increasing. Primary, secondary and tertiary preventative measures are warranted to prevent further escalation.
新生儿戒断综合征（NAS）是婴儿因子宫内接触药物而出现戒断症状的临床表现。20世纪70年代和80年代，都柏林妇产医院的NAS发病率随着该市阿片类药物滥用的增加而上升。本研究的目的是确定科克大学妇产医院是否也出现了类似的模式。对艾琳维尔医院（2000 - 2007年）和科克大学妇产医院（2008 - 2011年）的数据进行了比较。共确定了16例NAS病例，其中艾琳维尔医院2例（分娩22987例；发病率 = 0.09/1000例分娩），科克大学妇产医院14例（分娩37414例；发病率 = 0.38/1000例分娩；p < 0.01）。16位母亲中有5位使用海洛因，10位接受美沙酮维持治疗。所有母亲均为多药滥用者。与需要支持性护理的新生儿相比，因NAS需要药物治疗的新生儿（5/16）住院时间延长。科克的NAS发病率正在上升。有必要采取一级、二级和三级预防措施以防止情况进一步恶化。
