Section of Transfusion Medicine, Department of Clinical Pathology, Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio.
Transfusion. 2014 Jun;54(6):1452-8. doi: 10.1111/trf.12623. Epub 2014 Mar 24.
The molecular basis of many blood group antigens is known, and it provides a means for predicting the red blood cell phenotype. Molecular typing methods are useful when serologic typing cannot be performed, due to sample or reagent limitations. We discuss the implementation of a commercial molecular typing assay at our Transfusion Service, the indications for testing, and the advantages and drawbacks of the assay. We also present our algorithm for selecting candidates for testing.
许多血型抗原的分子基础已为人所知，这为预测红细胞表型提供了一种手段。当由于样本或试剂限制而无法进行血清学分型时，分子分型方法很有用。我们讨论了在我们的输血科实施商业分子分型检测的情况，包括检测的适应证，以及该检测的优缺点。我们还介绍了选择候选者进行检测的算法。
