Kitchen A D, Chiodini P L, Tossell J
National Transfusion Microbiology, NHS Blood & Transplant, London, UK.
Vox Sang. 2014 Aug;107(2):123-31. doi: 10.1111/vox.12142. Epub 2014 Mar 21.
The English transfusion service has screened donations from malaria-risk donors for malarial antibodies for over 10 years. The donor population includes migrants from many malaria-endemic countries and, from our experiences with post-transfusion malaria, some of these may remain parasitaemic and need clinical review.
Malarial antibody screen-reactive donations with serological evidence of malaria identified by the reference laboratory were further investigated for the presence of malarial DNA.
Malarial DNA was found in 14 of 1955 samples investigated; three P. falciparum, five P. vivax, three P. ovale, two P. malariae and one dual parasitaemia P. falciparum/P. malariae. All of these were donors whose malaria risk was residency rather than travel.
Malarial parasitaemia in healthy donors occurs, and donor malaria-risk strategies must take into account the possibility of such donors presenting. Countries not utilizing malarial antibody screening should consider carefully the collection of donations from donors previously resident in endemic countries; temporary deferral is insufficient.
英国输血服务机构对有疟疾感染风险的献血者进行疟疾抗体筛查已超过10年。献血人群包括来自许多疟疾流行国家的移民，根据我们对输血后疟疾的经验，其中一些人可能仍有疟原虫血症，需要临床检查。
对参考实验室鉴定出的有疟疾血清学证据且疟疾抗体筛查呈反应性的献血样本，进一步检测疟原虫DNA。
在1955份被调查样本中，有14份检测到疟原虫DNA；其中3份为恶性疟原虫，5份为间日疟原虫，3份为卵形疟原虫，2份为三日疟原虫，1份为恶性疟原虫/三日疟原虫双重感染。所有这些献血者感染疟疾的风险因素是长期居住而非旅行。
健康献血者中存在疟原虫血症，献血者疟疾风险策略必须考虑到这类献血者出现的可能性。未采用疟疾抗体筛查的国家应仔细考虑采集曾居住在流行国家的献血者的血液；仅临时延期献血是不够的。
