Ciralsky Jessica B, Chapman Kristin Ow, Rosenblatt Mark I, Sood Priyanka, Fernandez Ana G Alzaga, Lee Michelle N, Sippel Kimberly C
Department of Ophthalmology, Weill Cornell Medical College, New York -Presbyterian , New York, NY , USA.
Ocul Immunol Inflamm. 2015 Jun;23(3):219-24. doi: 10.3109/09273948.2014.894084. Epub 2014 Mar 21.
To evaluate continuous wear of a fluid-ventilated, gas-permeable scleral PROSE device using a standardized protocol as treatment for refractory persistent corneal epithelial defects in patients with severe ocular surface disease.
Retrospective review of eight eyes of seven consecutive patients with persistent epithelial defects refractory to traditional therapies. The standardized treatment regimen consisted of: (1) 24-hour-a-day PROSE wear until re-epithelialization was achieved, (2) brief daily device removal, cleaning, disinfection, and reservoir fluid replacement, (3) addition of a benzalkonium chloride (BAK)-free fourth-generation fluoroquinolone antibiotic drop to the reservoir, and (4) transition to long-term, daytime PROSE wear upon re-epithelialization.
All eight eyes exhibited resolution of the persistent epithelial defect. No eyes developed microbial keratitis. Four eyes exhibited recurrences; all recurrences promptly responded to reinstitution of continuous wear.
Continuous wear of a PROSE device, using a strictly standardized regimen, constitutes an effective, safe treatment option for refractory persistent epithelial defects.
采用标准化方案评估一种液体通气的透气巩膜PROSE装置持续佩戴，作为严重眼表疾病患者难治性持续性角膜上皮缺损的治疗方法。
回顾性分析7例连续患者的8只眼，这些患者的持续性上皮缺损对传统治疗无效。标准化治疗方案包括：（1）每天佩戴PROSE 24小时，直至上皮重新形成；（2）每天短暂取下装置，进行清洁、消毒和更换储液器中的液体；（3）在储液器中添加不含苯扎氯铵（BAK）的第四代氟喹诺酮抗生素滴眼液；（4）上皮重新形成后过渡到长期白天佩戴PROSE。
所有8只眼的持续性上皮缺损均得到解决。没有眼睛发生微生物性角膜炎。4只眼出现复发；所有复发在重新开始持续佩戴后均迅速得到缓解。
采用严格标准化方案持续佩戴PROSE装置，是治疗难治性持续性上皮缺损的一种有效、安全的治疗选择。
