六氯环己烷（HCH）与氯苯胺灵（CIPC）在雄性大鼠体内的相互作用。

Interaction of hexachlorocyclohexane (HCH) and chlorpropham (CIPC) in male rats.

作者信息

Dikshith T S, Carrera G, Raizada R B, Mitjavila S

机构信息

Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India.

出版信息

Toxicol Lett. 1989 Feb;45(2-3):281-8. doi: 10.1016/0378-4274(89)90019-2.

DOI:10.1016/0378-4274(89)90019-2

PMID:2465584

Abstract

Hexachlorocyclohexane (60.0 mg/kg/d) and chlorpropham (50.0 mg/kg/d) given to male rats daily orally for 30 d caused subtle biochemical lesions. The significant rise in the activity of alkaline phosphatase in liver and serum and of GOT and GPT in liver with substantial weight increase of liver has been suggestive of the initiation of biochemical lesions and adaptation of the organism. Very severe hepatocellular damage is forecasted if the pesticides are given for a prolonged period and in higher concentrations to animals.

摘要

每天给雄性大鼠口服六氯环己烷（60.0毫克/千克/天）和氯苯胺灵（50.0毫克/千克/天），持续30天，会导致细微的生化损伤。肝脏和血清中碱性磷酸酶活性以及肝脏中谷草转氨酶和谷丙转氨酶活性显著升高，同时肝脏重量大幅增加，这表明生化损伤的开始以及机体的适应性变化。如果长期以更高浓度给动物施用这些农药，预计会造成非常严重的肝细胞损伤。