Díez Javier
Department of Cardiovascular Sciences, Centre of Applied Medical Research, Pamplona, Spain; Department of Cardiology and Cardiac Surgery, University Clinic, Pamplona, Spain; University of Navarra, Pamplona, Spain.
Heart Fail Clin. 2014 Apr;10(2):233-42. doi: 10.1016/j.hfc.2013.12.004.
Hypertensive heart disease (HHD) has been considered the adaptive hypertrophy of the left ventricle wall to increased blood pressure. Recent findings in hypertensive animals and patients now challenge this paradigm by showing that HHD also results from pathologic structural remodeling of the myocardium in response to hemodynamic and nonhemodynamic factors that are altered in arterial hypertension. The possibility that hypertensive patients predisposed to develop heart failure may be detected before the appearance of clinical manifestations provides a new way to prevent this major arterial complication.
高血压性心脏病（HHD）一直被认为是左心室壁对血压升高的适应性肥厚。近期在高血压动物和患者中的研究发现，通过表明HHD也是心肌对动脉高血压中改变的血流动力学和非血流动力学因素作出反应而发生病理结构重塑的结果，对这一范式提出了挑战。在临床表现出现之前就检测出易发生心力衰竭的高血压患者的可能性，为预防这一主要的动脉并发症提供了新途径。
