心力衰竭患者的睡眠呼吸障碍
Sleep-disordered breathing in patients with heart failure.
作者信息
Mentz Robert J, Fiuzat Mona
机构信息
Duke University Medical Center, Duke Clinical Research Institute, 2301 Erwin Road, Durham, NC 27710, USA.
Duke University Medical Center, Duke Clinical Research Institute, 2301 Erwin Road, Durham, NC 27710, USA.
出版信息
Heart Fail Clin. 2014 Apr;10(2):243-50. doi: 10.1016/j.hfc.2013.10.001. Epub 2014 Jan 10.
Abstract
Sleep-disordered breathing (SDB) is prevalent in patients with heart failure, and is associated with increased morbidity and mortality. SDB is proinflammatory, with nocturnal oxygen desaturations and hypercapnia appearing to play a pivotal role in the development of oxidative stress and sympathetic activation. Preliminary data suggest that attention to the diagnosis and management of SDB in patients with heart failure may improve outcomes. Ongoing research into the roles of comorbidities such as SDB as a treatment target may lead to better clinical outcomes and improved quality of life for patients with heart failure.
摘要
睡眠呼吸紊乱（SDB）在心力衰竭患者中很常见，并且与发病率和死亡率增加相关。SDB具有促炎作用，夜间氧饱和度降低和高碳酸血症似乎在氧化应激和交感神经激活的发展中起关键作用。初步数据表明，关注心力衰竭患者SDB的诊断和管理可能会改善预后。对诸如SDB等合并症作为治疗靶点的作用进行的正在进行的研究可能会为心力衰竭患者带来更好的临床结果和更高的生活质量。
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