Baneu Petru, Văcărescu Cristina, Drăgan Simona-Ruxanda, Cirin Liviu, Lazăr-Höcher Alexandra-Iulia, Cozgarea Andreea, Faur-Grigori Adelina-Andreea, Crișan Simina, Gaiță Dan, Luca Constantin-Tudor, Cozma Dragoș
Doctoral School, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Department of Cardiology, "Victor Babes" University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.
Biomedicines. 2024 Jul 5;12(7):1493. doi: 10.3390/biomedicines12071493.
Given the widespread occurrence of insulin resistance, a key factor in metabolic syndrome and a distinct condition altogether, there is a clear need for effective, surrogate markers. The triglyceride-to-high-density lipoprotein (TG/HDL) ratio stands out as a viable option, indicative of changes in lipid metabolism associated with insulin resistance, offering a cost-effective and straightforward alternative to traditional, more complex biomarkers. This review, in line with PRISMA guidelines, assesses the TG/HDL ratio's potential as an indirect indicator of insulin resistance. Analysing 32 studies over 20 years, involving 49,782 participants of diverse ethnic backgrounds, including adults and children, this review primarily uses a cross-sectional analysis with the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) to gauge insulin resistance. It reveals the TG/HDL ratio's varied predictive power across ethnicities and sexes, with specific thresholds providing greater accuracy for Caucasians, Asians, and Hispanics over African Americans and for men over women. Valid across different weights and ages, for adults and children, it suggests average cutoffs of 2.53 for women and 2.8 for men. The analysis supports the TG/HDL ratio as a simple, accessible marker for insulin resistance, though it advises further research on tailored cutoffs reflecting ethnic and gender differences.
鉴于胰岛素抵抗的广泛存在，它是代谢综合征的一个关键因素，并且是一种完全不同的病症，因此显然需要有效的替代标志物。甘油三酯与高密度脂蛋白（TG/HDL）的比值是一个可行的选择，它表明了与胰岛素抵抗相关的脂质代谢变化，为传统的、更为复杂的生物标志物提供了一种经济高效且简便的替代方案。本综述符合PRISMA指南，评估了TG/HDL比值作为胰岛素抵抗间接指标的潜力。通过分析20年间的32项研究，涉及49782名不同种族背景的参与者，包括成人和儿童，本综述主要采用横断面分析，并结合胰岛素抵抗稳态模型评估（HOMA-IR）来衡量胰岛素抵抗。研究揭示了TG/HDL比值在不同种族和性别的预测能力存在差异，特定阈值对高加索人、亚洲人和西班牙裔的预测准确性高于非裔美国人，对男性的预测准确性高于女性。该比值在不同体重和年龄的成人及儿童中均有效，建议女性的平均临界值为2.53，男性为2.8。分析结果支持TG/HDL比值作为胰岛素抵抗的一个简单、易获取的标志物，不过建议针对反映种族和性别差异的特定临界值开展进一步研究。
