人α干扰素预处理对金黄色葡萄球菌诱导人血沉棕黄层白细胞产生干扰素的启动作用。
Priming of Staphylococcus aureus-induced interferon production in human buffy coat leukocytes by human interferon-alpha pretreatment.
作者信息
Rosztóczy I
机构信息
Institute of Microbiology, University Medical School, Szeged, Hungary.
出版信息
Acta Microbiol Hung. 1988;35(3):323-5.
Human buffy coat leukocytes produced interferon (IFN) in response to induction with heat-killed Staphylococcus aureus. Pretreatment of cell with 150 IU/ml human interferon-alpha (HuIFN-alpha) for 3 h enhanced the IFN production by about four- to eight-fold. The simultaneous presence of HuIFN-alpha and gamma in the culture supernatants was indicated by parallel titrations on human embryo fibroblasts (HEF) and MadinDarby bovine kidney (MDBK) cells and also by the distribution of the peak IFN activities after Sephacryl S-200 gel filtration.
人血沉棕黄层白细胞在经热灭活的金黄色葡萄球菌诱导后可产生干扰素（IFN）。用150 IU/ml的人α干扰素（HuIFN-α）预处理细胞3小时，可使IFN的产生增强约4至8倍。通过在人胚成纤维细胞（HEF）和马-达二氏牛肾（MDBK）细胞上的平行滴定以及经Sephacryl S-200凝胶过滤后IFN活性峰的分布，表明培养上清液中同时存在HuIFN-α和γ。
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