Rosztóczy I, Megyeri K
Institute of Microbiology, A. Szent-Györgyi Medical University, Szeged - Hungary.
J Biol Regul Homeost Agents. 1989 Jan-Mar;3(1):35-8.
Intramuscular (i.m.) injection of mice with 2000 IU/g of essentially pure murine interferon-alpha/beta (MuIFN-alpha/beta) 3 h before the induction of IFN by an intraperitoneal (i.p.) inoculation of 10 haemagglutinating units (HAU) per g Sendai virus or 3 micrograms/g polyriboinosinic and polyribocytidylic acid complex (poly rI:rC) elicited a primed IFN response in both cases. Antiserum to MuIFN-alpha/beta neutralized both the priming and antiviral activities of the IFN preparation used. Comparison of the kinetics of primed and unprimed IFN production by Sendai virus indicated that the early (2-4 h) period of IFN production was affected.
在通过腹腔注射每克10个血凝单位（HAU）仙台病毒或每克3微克聚肌苷酸和聚胞苷酸复合物（聚rI：rC）诱导干扰素之前3小时，给小鼠肌肉注射每克2000国际单位的基本纯的鼠干扰素α/β（MuIFN-α/β），在这两种情况下均引发了预刺激的干扰素反应。抗MuIFN-α/β血清中和了所用干扰素制剂的预刺激活性和抗病毒活性。对仙台病毒引发和未引发的干扰素产生动力学的比较表明，干扰素产生的早期（2 - 4小时）阶段受到了影响。
