Bal-Demirci Tülay, Sahin Musa, Ozyürek Mustafa, Kondakçı Esin, Ulküseven Bahri
Department of Chemistry, Inorganic Chemistry Section, Istanbul University, 34320 Avcilar, Istanbul, Turkey.
Department of Chemistry, Inorganic Chemistry Section, Istanbul University, 34320 Avcilar, Istanbul, Turkey.
Spectrochim Acta A Mol Biomol Spectrosc. 2014 May 21;126:317-23. doi: 10.1016/j.saa.2014.02.039. Epub 2014 Feb 24.
The nickel(II), iron(III) and oxovanadium(IV) complexes of the N2O2 chelating thiosemicarbazones were synthesized using 4-hydroxysalicyladehyde-S-methylthiosemicarbazone and R1-substitute-salicylaldehyde (R1: 4-OH, H) in the presence of Ni(II), Fe(III), VO(IV) ions by the template reaction. The structures of the thiosemicarbazone complexes were characterized by FT-IR, (1)H NMR, elemental, ESI-MS and APCI-MS analysis. The synthesized compounds were screened for their antioxidant capacity by using the cupric reducing antioxidant capacity (CUPRAC) method. Trolox equivalent antioxidant capacity (TEAC) of iron(III) complex, 1c, was measured to be higher than that of the other complexes. Other parameters of antioxidant activity (scavenging effects on •OH, O2(•-) and H2O2) of these compounds were also determined. All the compounds have shown encouraging ROS scavenging activities.
通过模板反应，在镍（II）、铁（III）、氧钒（IV）离子存在的情况下，使用4-羟基水杨醛-S-甲基硫代卡巴腙和R1-取代水杨醛（R1：4-OH，H）合成了N2O2螯合硫代卡巴腙的镍（II）、铁（III）和氧钒（IV）配合物。通过傅里叶变换红外光谱（FT-IR）、核磁共振氢谱（1H NMR）、元素分析、电喷雾电离质谱（ESI-MS）和大气压化学电离质谱（APCI-MS）分析对硫代卡巴腙配合物的结构进行了表征。使用铜离子还原抗氧化能力（CUPRAC）方法对合成的化合物进行抗氧化能力筛选。测得铁（III）配合物1c的特罗克斯当量抗氧化能力（TEAC）高于其他配合物。还测定了这些化合物抗氧化活性的其他参数（对•OH、O2(•-)和H2O2的清除作用）。所有化合物均表现出令人鼓舞的活性氧清除活性。
