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一种新型的计算机认知筛查测试能否为早期发现阿尔茨海默病提供更多信息?

Can a novel computerized cognitive screening test provide additional information for early detection of Alzheimer's disease?

机构信息

Gerontechnology and Rehabilitation Group, University of Bern, Bern, Switzerland; Clinical & Biological Psychology, Institute of Psychology and Education, University of Ulm, Ulm, Germany.

3rd Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.

出版信息

Alzheimers Dement. 2014 Nov;10(6):790-8. doi: 10.1016/j.jalz.2014.01.002. Epub 2014 Mar 18.

Abstract

BACKGROUND

Virtual reality testing of everyday activities is a novel type of computerized assessment that measures cognitive, executive, and motor performance as a screening tool for early dementia. This study used a virtual reality day-out task (VR-DOT) environment to evaluate its predictive value in patients with mild cognitive impairment (MCI).

METHODS

One hundred thirty-four patients with MCI were selected and compared with 75 healthy control subjects. Participants received an initial assessment that included VR-DOT, a neuropsychological evaluation, magnetic resonance imaging (MRI) scan, and event-related potentials (ERPs). After 12 months, participants were assessed again with MRI, ERP, VR-DOT, and neuropsychological tests.

RESULTS

At the end of the study, we differentiated two subgroups of patients with MCI according to their clinical evolution from baseline to follow-up: 56 MCI progressors and 78 MCI nonprogressors. VR-DOT performance profiles correlated strongly with existing predictive biomarkers, especially the ERP and MRI biomarkers of cortical thickness.

CONCLUSIONS

Compared with ERP, MRI, or neuropsychological tests alone, the VR-DOT could provide additional predictive information in a low-cost, computerized, and noninvasive way.

摘要

背景

日常活动的虚拟现实测试是一种新型的计算机评估方法,可作为早期痴呆症的筛查工具,衡量认知、执行和运动能力。本研究使用虚拟现实外出任务 (VR-DOT) 环境来评估其在轻度认知障碍 (MCI) 患者中的预测价值。

方法

选择了 134 名 MCI 患者,并与 75 名健康对照组进行了比较。参与者接受了初步评估,包括 VR-DOT、神经心理学评估、磁共振成像 (MRI) 扫描和事件相关电位 (ERP)。12 个月后,再次对参与者进行 MRI、ERP、VR-DOT 和神经心理学测试评估。

结果

在研究结束时,我们根据患者从基线到随访的临床演变将 MCI 患者分为两个亚组:56 名 MCI 进展者和 78 名 MCI 非进展者。VR-DOT 表现与现有的预测生物标志物密切相关,尤其是 ERP 和皮质厚度的 MRI 生物标志物。

结论

与 ERP、MRI 或神经心理学测试单独相比,VR-DOT 可以以低成本、计算机化和非侵入性的方式提供额外的预测信息。

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