Geevasinga Nimeshan, Cole Catherine, Herkes Geoffrey K, Barnett Yael, Lin Jamie, Needham Merrilee
Department of Neurology, Royal North Shore Hospital, Reserve Road, St Leonards, Sydney, NSW 2065, Australia; Western Clinical School, University of Sydney, Sydney, NSW, Australia.
School of Paediatrics and Child Health, University of Western Australia, Crawley, WA, Australia; Departments of Paediatric and Adolescent Haematology and Oncology, Princess Margaret Hospital for Children, Perth, WA, Australia.
J Clin Neurosci. 2014 Aug;21(8):1329-32. doi: 10.1016/j.jocn.2013.10.028. Epub 2014 Jan 24.
Sickle cell disease can present with neurological manifestations. One such presentation is with posterior reversible leukoencephalopathy also known as reversible posterior leukoencephalopathy. The condition is classically described as reversible over time; it commonly presents with oedematous changes involving the white matter of the occipital and parietal regions. Only a few patients with the association between sickle cell disease and posterior reversible leukoencephalopathy have been described in the adult literature. We present two patients from our institutions to emphasise the association between the two conditions and summarise the published cases in the literature.
镰状细胞病可出现神经学表现。其中一种表现是后部可逆性白质脑病，也称为可逆性后部白质脑病。这种情况通常被描述为随时间推移可逆转；它通常表现为涉及枕叶和顶叶白质的水肿性改变。成人文献中仅描述了少数患有镰状细胞病与后部可逆性白质脑病关联的患者。我们展示了来自我们机构的两名患者，以强调这两种情况之间的关联，并总结文献中已发表的病例。
