Luther H, Altmeyer P
Dermatological Department, Ruhr University, Bochum, F.R.G.
Am J Dermatopathol. 1988 Oct;10(5):390-8.
Secondary alteration of eccrine sweat glands is frequent in neoplastic and inflammatory skin diseases. The histological changes are characterized by a remarkable variability. However, a systematic classification of these reactions does not exist. We examined routine histological sections of biopsy specimens and found morphological alterations of eccrine sweat gland in the secretory coil, the duct, and the surrounding connective tissue. Dilation with or without retention was the most common histological variation seen in the secretory segments and the ducts. In association with dilation, flattening of the secretory and ductal cells occurs. Other cell changes were hydropic alteration and vacuolization of the secretory cells; seldom was a thickening of the cuticle observed. A striking phenomenon was the proliferation of ductal epithelium in different skin tumors. We found histological changes of the surrounding connective tissue less frequently: marked periglandular fibrosis and mucinous degeneration occurred.
小汗腺的继发性改变在肿瘤性和炎症性皮肤病中很常见。组织学变化具有显著的变异性。然而，目前尚无对这些反应的系统分类。我们检查了活检标本的常规组织切片，发现小汗腺在分泌盘曲部、导管及周围结缔组织存在形态学改变。分泌段和导管中最常见的组织学变化是伴有或不伴有潴留的扩张。与扩张相关的是，分泌细胞和导管细胞变扁平。其他细胞变化包括分泌细胞的水样变性和空泡化；很少观察到角质层增厚。一个显著的现象是不同皮肤肿瘤中导管上皮的增生。我们较少发现周围结缔组织的组织学变化：出现明显的腺周纤维化和黏液变性。
