Saida T, Uhara H, Mikoshiba H
Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.
Dermatologica. 1989;179(1):25-8.
Phytohemagglutinin (PHA)-binding sites were histochemically investigated in normal adult skin and various skin tumors using peroxidase-labeled lectin. In the normal skin, acrosyringium and distal portion of intradermal duct of eccrine and apocrine sweat glands were intensely stained with PHA. Other elements of the skin were virtually negative. Among various kinds of sweat gland tumors and other skin tumors, syringoma and eccrine porocarcinoma were intensely stained with PHA. Small ductal structures of nodular hidradenoma and mixed tumor of the skin were also stained with PHA. No other skin tumors were positive with PHA staining. The present study clearly showed that PHA is a useful histochemical marker of distal portion of eccrine and apocrine sweat ducts.
采用过氧化物酶标记凝集素，对正常成人皮肤和各种皮肤肿瘤中的植物血凝素（PHA）结合位点进行了组织化学研究。在正常皮肤中，小汗腺和大汗腺的顶泌汗腺导管及真皮内导管远端被PHA强烈染色。皮肤的其他成分几乎呈阴性。在各种汗腺肿瘤和其他皮肤肿瘤中，汗管瘤和小汗腺导管癌被PHA强烈染色。结节性汗腺瘤和皮肤混合瘤的小导管结构也被PHA染色。没有其他皮肤肿瘤PHA染色呈阳性。本研究清楚地表明，PHA是小汗腺和大汗腺导管远端的一种有用的组织化学标记物。
