Burke Chris, Shalhub Sherene, Starnes Benjamin W
Division of Vascular Surgery, Department of Surgery, University of Washington, Seattle, Wash.
Division of Vascular Surgery, Department of Surgery, University of Washington, Seattle, Wash.
J Vasc Surg. 2015 Aug;62(2):486-8. doi: 10.1016/j.jvs.2014.01.049. Epub 2014 Mar 20.
Aneurysms of the internal mammary artery are rare. We describe a case of a 49-year-old woman with a SMAD3 mutation who presented with left internal mammary artery aneurysm that was thought to have ruptured, causing a large spontaneous left mediastinal hematoma. The aneurysm was treated successfully months after initial presentation with coil embolization. SMAD3 mutations are linked to familial thoracic aortic aneurysms and dissections, peripheral aneurysms, and early-onset osteoarthritis, with an estimated incidence of 2% in families with familial thoracic aortic aneurysms and dissections. To our knowledge, this is the first case in the literature to link a SMAD3 mutation with internal mammary artery aneurysm.
乳内动脉动脉瘤较为罕见。我们描述了一例49岁患有SMAD3突变的女性病例，该患者出现左乳内动脉动脉瘤，据认为已破裂，导致左纵隔自发性大血肿。动脉瘤在初次就诊数月后通过弹簧圈栓塞成功治疗。SMAD3突变与家族性胸主动脉瘤和夹层、周围动脉瘤以及早发性骨关节炎有关，在患有家族性胸主动脉瘤和夹层的家族中估计发病率为2%。据我们所知，这是文献中首例将SMAD3突变与乳内动脉动脉瘤相关联的病例。
