Leite Rachel C, Souza Ariani I, Castanha Priscila M S, Cordeiro Marli T, Martelli Celina T, Ferreira Ana Laura G, Katz Leila, Braga Cynthia
Instituto de Medicina Integral Prof. Fernando Figueira - IMIP, Rua dos Coelhos, 300, Boa Vista, Recife, Pernambuco CEP 50070-550, Brazil.
Centro de Pesquisas Aggeu Magalhães - FIOCRUZ, Av. Prof. Moraes Rego, s/n, Recife, Cidade Universitária, Pernambuco CEP 50.670-420, Brazil.
J Clin Virol. 2014 May;60(1):16-21. doi: 10.1016/j.jcv.2014.02.009. Epub 2014 Mar 2.
Dengue affects nearly 400 million people annually worldwide and considered one of the most serious health threats in tropical and subtropical countries.
To analyze the occurrence of dengue infection among the parturient who have formed the baseline of an ongoing birth cohort study in the city of Recife, Northeast of Brazil.
From March 2011 to May 2012, we recruited 417 parturients with low-risk pregnancies at maternity ward who agreed to a follow-up of their babies. Dengue infection was accessed through DENV RT-PCR and anti-dengue antibodies (IgM and IgG). The prevalence of IgG antibodies in the parturients and their concepts were determined. The concordance among the pairs was tested using Kappa. The association of recent infection (IgM and/or DENV RT-PCR positive) with the maternal characteristics and clinical features of the neonates was analyzed through logistic regression.
The prevalence of IgG antibodies in the maternal and cord blood samples was 95.1% (95% CI: 92.6-96.9%) and 95.8% (95% CI: 93.4-97.5%), respectively, with high agreement between maternal-cord pairs (Kappa=0.93). The prevalence of recent infection was 10.6% (95% CI: 7.9-14.2%) in the parturients. Reported fever during pregnancy was associated to recent infection (p=0.023).
The data draw attention for the high frequency of anti-dengue antibodies in the women studied and for the high occurrence of infection during pregnancy in this region of Brazil. There is a need for further studies to better characterize dengue infection in pregnant women.
登革热每年在全球影响近4亿人，被认为是热带和亚热带国家最严重的健康威胁之一。
分析在巴西东北部累西腓市一项正在进行的出生队列研究中作为基线的产妇中登革热感染的发生情况。
2011年3月至2012年5月，我们在产科病房招募了417例低风险妊娠的产妇，她们同意对其婴儿进行随访。通过登革病毒逆转录聚合酶链反应（DENV RT-PCR）和抗登革热抗体（IgM和IgG）检测登革热感染情况。测定产妇及其新生儿中IgG抗体的患病率。使用Kappa检验配对之间的一致性。通过逻辑回归分析近期感染（IgM和/或DENV RT-PCR阳性）与产妇特征及新生儿临床特征之间的关联。
产妇和脐带血样本中IgG抗体的患病率分别为95.1%（95%可信区间：92.6 - 96.9%）和95.8%（95%可信区间：93.4 - 97.5%），产妇与脐带配对之间一致性较高（Kappa = 0.93）。产妇中近期感染的患病率为10.6%（95%可信区间：7.9 - 14.2%）。孕期报告发热与近期感染相关（p = 0.023）。
这些数据引起人们对所研究女性中抗登革热抗体的高频率以及巴西该地区孕期感染的高发生率的关注。需要进一步研究以更好地描述孕妇中的登革热感染情况。
