Armitage Sophie A O, Peuss Robert, Kurtz Joachim
Institute for Evolution and Biodiversity, University of Münster, Hüfferstrasse 1, 48149 Münster, Germany.
Dev Comp Immunol. 2015 Feb;48(2):315-23. doi: 10.1016/j.dci.2014.03.004. Epub 2014 Mar 19.
Evidence is accumulating for a memory-like phenomenon in the immune defence of invertebrates. Down syndrome cell adhesion molecule (Dscam) has been proposed as a key candidate for a somatically diversified receptor system in the crustaceans and insects (Pancrustacea) that could enable challenge-specific protection. However, what is the evidence for an involvement of Dscam in pancrustacean immune memory, and in particular specificity? Here we review the current state of the art, and discuss hypotheses of how Dscam could be involved in immunity. We conclude that while there is increasing evidence for the involvement of Dscam in pancrustacean immunity, crucial experiments to address whether it plays a role in specificity upon secondary encounter with a pathogen still remain to be done.
越来越多的证据表明，无脊椎动物的免疫防御中存在类似记忆的现象。唐氏综合征细胞粘附分子（Dscam）被认为是甲壳类动物和昆虫（泛甲壳动物）体细胞多样化受体系统的关键候选者，该系统能够实现针对特定挑战的保护。然而，有哪些证据表明Dscam参与了泛甲壳动物的免疫记忆，特别是特异性免疫记忆呢？在这里，我们回顾了当前的技术水平，并讨论了Dscam可能参与免疫的假说。我们的结论是，虽然越来越多的证据表明Dscam参与了泛甲壳动物的免疫，但关于它在再次接触病原体时是否在特异性免疫中发挥作用的关键实验仍有待进行。
