肿瘤位置是中国 T1-2N0M0 期乳腺癌女性生存的预后因素。
Tumor location is a prognostic factor for survival of Chinese women with T1-2N0M0 breast cancer.
机构信息
Xiamen Cancer Center, Department of Radiation Oncology, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China.
Xiamen Cancer Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China.
出版信息
Int J Surg. 2014;12(5):394-8. doi: 10.1016/j.ijsu.2014.03.011. Epub 2014 Mar 20.
OBJECTIVE
The purpose of this study was to investigate the effects of primary tumor location on the survival of Chinese women with T1-2N0M0 breast cancer.
METHODS
The clinical data of 1044 patients with stage T1-2N0M0 breast cancer who were treated from 1999 to 2007 were retrospectively analyzed. Patients were divided according to the primary tumor location: upper-outer quadrant (UOQ), upper-inner quadrant (UIQ), lower-outer quadrant (LOQ), lower-inner quadrant (LIQ), and nipple and central breast (central). The effect of primary tumor location on recurrence-free survival (RFS) and overall survival (OS) were determined.
RESULTS
The median age at diagnosis was 47 years. The tumor was located in the UOQ in 524 patients (50.2%), the LOQ in 124 (11.9%), the UIQ in 229 (21.9%), the LIQ in 59 (5.7%), and centrally in 108 patients (10.3%). The 5- and 10-year RFS and OS of the LIQ group were significantly poorer than that of patients in the other groups (RFS: 72.1% vs. 82.2-86.7%, P = 0.041; OS: 73.6% vs. 85.3-89.1%, P = 0.024). Multivariate Cox analysis showed that primary tumor location in the LIQ was an independent prognostic factor for RFS (hazard ratio [HR] = 2.977; 95% confidence interval [CI] 1.219-7.273; P = 0.017) and OS (HR = 2.949; 95% CI 1.207-7.208; P = 0.018).
CONCLUSION
Primary tumor location is an important prognostic factor for survival of Chinese women with T1-2N0M0 breast cancer.
目的
本研究旨在探讨原发肿瘤位置对中国 T1-2N0M0 期乳腺癌患者生存的影响。
方法
回顾性分析 1999 年至 2007 年收治的 1044 例 T1-2N0M0 期乳腺癌患者的临床资料。根据原发肿瘤位置将患者分为：外上象限（UOQ）、外下象限（LOQ）、内上象限（UIQ）、内下象限（LIQ）和乳头及中央区（中央）。确定原发肿瘤位置对无复发生存率（RFS）和总生存率（OS）的影响。
结果
中位诊断年龄为 47 岁。524 例（50.2%）患者肿瘤位于 UOQ，124 例（11.9%）位于 LOQ，229 例（21.9%）位于 UIQ，59 例（5.7%）位于 LIQ，108 例（10.3%）位于中央区。LIQ 组的 5 年和 10 年 RFS 和 OS 明显差于其他组（RFS：72.1% vs. 82.2%-86.7%，P=0.041；OS：73.6% vs. 85.3%-89.1%，P=0.024）。多因素 Cox 分析显示，LIQ 原发肿瘤位置是 RFS（危险比[HR]=2.977；95%置信区间[CI]1.219-7.273；P=0.017）和 OS（HR=2.949；95%CI 1.207-7.208；P=0.018）的独立预后因素。
结论
原发肿瘤位置是中国 T1-2N0M0 期乳腺癌患者生存的重要预后因素。
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