伊朗德黑兰学术外科病房乳腺癌患者的临床特征：一项分析性横断面研究。

Clinical characteristics of breast cancer patients admitted to academic surgical wards in Tehran, Iran: an analytical cross-sectional study.

机构信息

Breast Diseases Research Center, Cancer Institute, Tehran University of Medical Sciences, Imam Khomeini Complex Hospital, 2nd Floor, Sadaf Building, Keshavraz Blvd, Tehran, 1419733141, Iran.

Department of Surgical Oncology, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

BMC Womens Health. 2023 Sep 25;23(1):511. doi: 10.1186/s12905-023-02637-0.

DOI:10.1186/s12905-023-02637-0

PMID:37743485

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10518944/

Abstract

BACKGROUND

Breast cancer (BC) is the most commonly diagnosed cancer and the leading cause of cancer death among women. Knowledge of the clinical characteristics of BC in a population may be informative for disease prediction or diagnosis and for developing screening and diagnostic guidelines. This study aimed to evaluate the clinical characteristics of female patients with BC who were admitted to academic surgical wards in Tehran, Iran.

METHODS

In this cross-sectional study, demographic information and clinical characteristics of Iranian females with BC who had undergone breast surgery from 2017-2021 in four academic Breast Surgery Units were extracted from medical files and recorded via a pre-designed checklist.

RESULTS

A total of 1476 patients with a mean age of 48.03 (± 11.46) years were enrolled. Among them, 10.4% were aged less than 35. In younger patients, Triple-negative and Her2-enriched subtypes of BC were significantly higher compared to older ones. Overall, 85.7% of tumors were invasive ductal carcinoma, 43.3% were grade 2, 41.4% were located in the UOQ, and 65.2% had presented with mass palpation. The mean pathologic tumor size was 28.94 mm, and the most common subtype was luminal B.

CONCLUSIONS

Many characteristics of breast cancer in this study were similar to other countries and previous studies in Iran. However, a higher proportion of young BC compared with Western countries, and even with older studies in Iran, suggest a trend toward lower age for BC in recent years. These results indicate the need for preventive measures and screening in Iranian women at a younger age.

摘要

背景

乳腺癌（BC）是最常见的癌症，也是女性癌症死亡的主要原因。了解人群中 BC 的临床特征可能有助于疾病预测或诊断，并有助于制定筛查和诊断指南。本研究旨在评估在伊朗德黑兰的学术外科病房住院的女性 BC 患者的临床特征。

方法

在这项横断面研究中，从 2017 年至 2021 年，从四个学术乳腺外科单位接受乳腺手术的伊朗女性 BC 患者的人口统计学信息和临床特征从病历中提取出来，并通过预先设计的检查表进行记录。

结果

共纳入了 1476 名平均年龄为 48.03（±11.46）岁的患者。其中，10.4%的患者年龄小于 35 岁。在年轻患者中，三阴性和 Her2 富集型 BC 的比例明显高于老年患者。总体而言，85.7%的肿瘤为浸润性导管癌，43.3%为 2 级，41.4%位于 UOQ，65.2%为扪及肿块。肿瘤的平均病理大小为 28.94mm，最常见的亚型为管腔 B 型。