Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan.
Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan.
Neurochem Int. 2014 May;70:30-8. doi: 10.1016/j.neuint.2014.03.008. Epub 2014 Mar 19.
The present study evaluated the effects of treatment with the citrus flavonoid, 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF) on protection against memory impairment and neuronal death in a global cerebral ischemia mouse model. The results showed that HMF, administrated for three days immediately after ischemic surgery, protected against ischemia-induced memory dysfunction, rescued neuronal cell death in the CA1 cell layer, increased the production of BDNF, stimulated the autophosphorylation of CaMK II and suppressed microglial activation in the hippocampus. These results suggest that HMF has a neuroprotective effect after brain ischemia by inducing BDNF production and anti-inflammatory effects.
本研究评估了用柑橘类黄酮，3,5,6,7,8,3',4'-七甲氧基黄酮（HMF）治疗对全脑缺血小鼠模型的记忆障碍和神经元死亡保护作用的影响。结果表明，HMF 在缺血手术后立即连续 3 天给药，可防止缺血引起的记忆功能障碍，挽救 CA1 细胞层的神经元细胞死亡，增加 BDNF 的产生，刺激海马 CA1 区 CaMK II 的自磷酸化，并抑制小胶质细胞激活。这些结果表明，HMF 通过诱导 BDNF 的产生和抗炎作用，在脑缺血后具有神经保护作用。
