Garin A M, Tiuliandin S A, Abdyldaev T A, Khlebnov A V, Kupchan D Z
Antibiot Khimioter. 1988 Nov;33(11):855-9.
Efficacy and toxicity of VAB-6 combinations with bleomycin, bleomycetin or peplomycin were studied in treatment of 77 patients with metastases of germ-cell tumors: testicle tumors in 71 patients and extragonadal tumors in 6 patients. After the chemotherapy complete regression was observed in 37 patients (48.7 per cent). In 44 patients (57.1 per cent) residual metastases after the chemotherapy were resected. The frequency of complete regression after using the VAB-6 combinations with bleomycin, bleomycetin and peplomycin amounted to 58.8, 61.5 and 47.1 per cent respectively. The treatment results depended on the disease extent. When the disease extent was minimal complete regression was observed in 87.5 per cent of the patients. The respective figures for the disease moderate and significant extents were 66.7 and 37.8 per cent. During the average observation period of 22.1 months (7-40 months) 39 patients survived and had no signs of the disease. The combinations markedly differed in their toxicity.
研究了VAB - 6联合博来霉素、平阳霉素或培洛霉素治疗77例生殖细胞肿瘤转移患者的疗效和毒性：71例睾丸肿瘤患者和6例性腺外肿瘤患者。化疗后，37例患者（48.7%）观察到完全缓解。44例患者（57.1%）化疗后的残留转移灶被切除。VAB - 6联合博来霉素、平阳霉素和培洛霉素后的完全缓解率分别为58.8%、61.5%和47.1%。治疗结果取决于疾病范围。当疾病范围最小时，87.5%的患者观察到完全缓解。疾病中度和重度范围的相应数字分别为66.7%和37.8%。在平均22.1个月（7 - 40个月）的观察期内，39例患者存活且无疾病迹象。这些联合方案在毒性方面有显著差异。
