Lichinitser M R, Tiuliandin S A
Antibiotiki. 1984 Jun;29(6):468-73.
The efficacy of the chemotherapy of 16 patients with metastases of malignant tumors of the testicle was studied. The chemotherapy included vinblastine, platidiam and bleomycetin. The latter was used in a dose of 10 mg daily intramuscularly or as long-term intravenous infusions. As a result of the treatment complete and partial regression of the tumors was observed in 5 (31 per cent) and 4 (25 per cent) patients, respectively. Leukopenia was the main side effect. By present the total doses of bleomycetin had amounted to 250 mg for 4 patients and to 300-350 mg for 7 patients. No signs of pulmonary toxicity were observed with the use of these doses. The problem of clinical studies of bleomycin analogs is discussed.
对16例睾丸恶性肿瘤转移患者的化疗疗效进行了研究。化疗药物包括长春碱、顺铂和博来霉素。博来霉素的使用剂量为每日10毫克，肌肉注射或长期静脉输注。治疗结果显示，分别有5例（31%）和4例（25%）患者的肿瘤完全缓解和部分缓解。白细胞减少是主要的副作用。目前，4例患者的博来霉素总剂量达250毫克，7例患者的总剂量为300 - 350毫克。使用这些剂量未观察到肺部毒性迹象。文中还讨论了博来霉素类似物的临床研究问题。
