Zharkov S A, Batov S V
Antibiot Khimioter. 1988 Nov;33(11):859-61.
Clinical trials on efficacy and toxicity of combined use of bleomycetin, 5-fluorouracil and cisplatin in patients with disseminated tumor processes were conducted. Two regimens were applied. Regimen I included intravenous administration of cisplatin in a dose of 100-150 mg/m2 on day 1, intramuscular administration of bleomycetin in a dose of 10 mg on days 2-4 and intravenous jet injection of 5-fluorouracil in a dose of 400 mg/m2 on days 2-4. Regimen II consisted of intramuscular administration of bleomycetin in a dose of 10 mg on days 1-3, intravenous jet injection of 5-fluorouracil in a dose of 400 mg/m2 on the same days and intravenous administration of cisplatin in a dose of 100-150 mg/m2 on day 4. The intervals between the courses amounted to 4 weeks. Complete regression of cervical carcinoma relapsing was observed in 1 patient. In 5 patients i.e. 1 with small-cell lung cancer, 3 with squamous cell lung cancer and 1 with metastases of low-differentiated cancer from an undetected focus to supraclavicular lymph nodes the effect was partial. Long-term stabilization of the disease at the background of the treatment for 6-7 months was stated in 3 patients. On the whole the objective response was in 6 out of 22 patients or in 27 per cent. 7 of them were treated with cisplatin in a dose of 150 mg/m2. The regimens of the combined use of 5-fluorouracil, bleomycetin and cisplatin were low toxic. The therapeutic effect showed that the combination was of practical value.
开展了关于博来霉素、5-氟尿嘧啶和顺铂联合应用于播散性肿瘤患者的疗效和毒性的临床试验。采用了两种治疗方案。方案I包括在第1天静脉注射顺铂，剂量为100 - 150mg/m²，在第2 - 4天肌肉注射博来霉素，剂量为10mg，在第2 - 4天静脉推注5-氟尿嘧啶，剂量为400mg/m²。方案II包括在第1 - 3天肌肉注射博来霉素，剂量为10mg，在同一天静脉推注5-氟尿嘧啶，剂量为400mg/m²，在第4天静脉注射顺铂，剂量为100 - 150mg/m²。疗程之间的间隔为4周。观察到1例复发性宫颈癌完全消退。在5例患者中，即1例小细胞肺癌、3例鳞状细胞肺癌和1例未检测到原发灶的低分化癌转移至锁骨上淋巴结的患者，疗效为部分缓解。3例患者在治疗6 - 7个月期间病情长期稳定。总体而言，22例患者中有6例出现客观缓解，占27%。其中7例接受了剂量为150mg/m²的顺铂治疗。5-氟尿嘧啶、博来霉素和顺铂联合使用的方案毒性较低。治疗效果表明该联合用药具有实际应用价值。
