针对基因组完整性维持和癌症易感性的小鼠基因筛选。

Genetic screens in mice for genome integrity maintenance and cancer predisposition.

作者信息

Balmus Gabriel, McIntyre Rebecca E

机构信息

The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK; Experimental Cancer Genetics, The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

Experimental Cancer Genetics, The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

出版信息

Curr Opin Genet Dev. 2014 Feb;24:1-7. doi: 10.1016/j.gde.2013.10.010. Epub 2013 Dec 13.

DOI:10.1016/j.gde.2013.10.010

PMID:24657530

Abstract

Genome instability is a feature of nearly all cancers and can be exploited for therapy. In addition, a growing number of genome maintenance genes have been associated with developmental disorders. Efforts to understand the role of genome instability in these processes will be greatly facilitated by a more comprehensive understanding of their genetic network. We highlight recent genetic screens in model organisms that have assisted in the discovery of novel regulators of genome stability and focus on the contribution of mice as a model organism to understanding the role of genome instability during embryonic development, tumour formation and cancer therapy.

摘要

基因组不稳定是几乎所有癌症的一个特征，并且可被用于治疗。此外，越来越多的基因组维持基因已与发育障碍相关联。对其遗传网络的更全面理解将极大地促进我们去了解基因组不稳定在这些过程中的作用。我们着重介绍了模式生物中最近的遗传筛选，这些筛选有助于发现基因组稳定性的新型调节因子，并聚焦于小鼠作为模式生物在理解胚胎发育、肿瘤形成和癌症治疗过程中基因组不稳定作用方面的贡献。