The Department of Pharmaceutical Technology, Poznan University of Medical Sciences, Grunwaldzka 6, Poznań 60-780, Poland.
The Department of Pharmaceutical Technology, Poznan University of Medical Sciences, Grunwaldzka 6, Poznań 60-780, Poland.
Int J Pharm. 2014 May 15;466(1-2):328-40. doi: 10.1016/j.ijpharm.2014.03.038. Epub 2014 Mar 20.
Over the past few decades, microbial polysaccharides have been under intense investigation due to their advantageous physicochemical properties. A great structural diversity of these biomolecules has led to multiple applications in food industry, personal care products, pharmacy and medicine. Currently, one of the most widely studied and fully described member of this group is gellan. It is a linear polymer produced by Sphingomonas elodea. A polymer chain of gellan consists of a tetrasaccharide repeating unit of l-rhamnose, d-glucose and d-glucuronate. So far most of the studies have been focused on the application of gellan as a food ingredient. However, due to the unique structure and beneficial properties, gellan is currently described as a potent multifunctional additive for various pharmaceutical products. Specific gelling properties in different media led to the development of controlled release forms based on gellan. Various formulations have been studied including oral, ophthalmic, nasal and other. Recent reports suggest that gellan-based materials can also be used in regenerative medicine, stomatology or gene transfer technology.
在过去的几十年中，由于微生物多糖具有有利的物理化学性质，它们受到了强烈的关注。这些生物分子具有很大的结构多样性，导致它们在食品工业、个人护理产品、制药和医学中有多种应用。目前，该类物质中研究最广泛、描述最全面的成员之一是结冷胶。它是由鞘氨醇单胞菌产生的线性聚合物。结冷胶的聚合物链由 l-鼠李糖、d-葡萄糖和 d-葡萄糖醛酸的四糖重复单元组成。到目前为止，大多数研究都集中在结冷胶作为食品成分的应用上。然而，由于其独特的结构和有益的特性，结冷胶目前被描述为各种药物产品的有效多功能添加剂。在不同介质中的特定胶凝特性导致了基于结冷胶的控释形式的发展。已经研究了各种制剂，包括口服、眼用、鼻用和其他制剂。最近的报告表明，基于结冷胶的材料也可用于再生医学、口腔医学或基因转移技术。
