Lin Che-Wei, Liu Tai-Hung, Chen Vincent, Chuang Er-Yuan, Fan Yu-Jui, Yu Jiashing
School of Biomedical Engineering, Taipei Medical University, Taipei, 10675, Taiwan.
Department of Chemical Engineering, National Taiwan University, Taipei, 10617, Taiwan.
Mater Today Bio. 2024 Jul 4;27:101146. doi: 10.1016/j.mtbio.2024.101146. eCollection 2024 Aug.
In recent years, the development of biodegradable hydrogels as an alternative over the traditional wound dressing has become increasingly significant. These specific hydrogels are able to offer suitable microenvironments to further aid the process of tissue or organ regeneration. However, application of biodegradable hydrogels in clinical medicine remains uncommon due to most biodegradable hydrogels struggle with achieving satisfactory adhesiveness property, high mechanical support and cell compatibility simultaneously. In order to overcome these constraints and enhance the applicability of biodegradable hydrogels, methods have been employed in this study. By reacting gellan gum with methacrylic anhydride and incorporating a biodegradable protein, keratin, we endowed the hydrogels with high pliability via photo-polymerization chain extension, thereby obtaining a biodegradable hydrogel with exceptional properties. Through a series of tests, GGMA/keratin hydrogels exhibited great cell compatibility via providing an appropriate environment for cell proliferation. Furthermore, this hydrogel not only exhibits extraordinary adhesive ability on visceral tissues but also extends to scenarios involving skin or organ damage, offering valuable assistance in wound healing. Our design provides a suitable platform for cell proliferation and tissue regeneration, which shows prospects for future medical research and clinical applications.
近年来，作为传统伤口敷料的替代品，可生物降解水凝胶的发展变得越来越重要。这些特定的水凝胶能够提供合适的微环境，以进一步辅助组织或器官再生过程。然而，可生物降解水凝胶在临床医学中的应用仍然不常见，因为大多数可生物降解水凝胶难以同时实现令人满意的粘附性、高机械支撑性和细胞兼容性。为了克服这些限制并提高可生物降解水凝胶的适用性，本研究采用了一些方法。通过使结冷胶与甲基丙烯酸酐反应并加入一种可生物降解的蛋白质——角蛋白，我们通过光聚合链延长赋予水凝胶高柔韧性，从而获得了具有优异性能的可生物降解水凝胶。通过一系列测试，GGMA/角蛋白水凝胶通过为细胞增殖提供适宜环境而表现出良好的细胞兼容性。此外，这种水凝胶不仅在内脏组织上表现出非凡的粘附能力，还扩展到涉及皮肤或器官损伤的情况，为伤口愈合提供了有价值的帮助。我们的设计为细胞增殖和组织再生提供了一个合适的平台，显示出未来医学研究和临床应用的前景。
